soal fbs 9 no 74-94

a 50 years old man complain severe headche a back head and generalized edema (anasarca)
74. Which of the following dieases is a most appropriate diagnostic ?
a. Cirrhosis
b. Heart Failure
c.. Elephatiasis
d. Nephrotic syndrom
e. Malnutrition

Jawab : B
Tanda-tandanya anasarca ,,nah sebenarnya kalau g heart failure itu nephrotic syndrome tapi lebih ke heart failure karena ada severe headhece nya

754. Which of the following dieses is the most appropriate diagnostic?
a. increase hydrostatic pressure
b. Reduce plasama osmotic pressure
c. Lymphatic obstruction
d. Sodium retention
e. Impaire venous return

Jawab E
Dari Robin Contran, kalau orang heart faillure maka CO turun nah akibatnya venous return juga turun, trus knapa bisa anasarca???? akibatnya perfusi gnjal berkurang sehingga ada retensi garam dan air, nah kalau sakit kepalanya kalau menurut saya sih karena kurangnya asupan darah ke otak..(tp itu cuma hipotesis ya...)

76. If in patient is found large ammount acumulation of blood in body cavity. What is the appropriate term for this condition ?
a. Petechiae
b. Purpura
c. Echymoses
d. HEmotoraxis
e. HEmipericardium

Jawaban: Punten belum dapet, tapi mungkin hemotoraxis

77. What is patogenesis of trombosis ?
a. endotelial injury
b. turbulance
c. Statis blood flow
d. Hypercoagulability
e. Rupture of the arterial

Jawab : a. endotelial injury, dari slide

78. Which one of the statment is including in being favor thrombosis
a. Trombomodulin
b. Von will brand factor
c. Tissue type plasminogen activator
d. Protacyclin
e. Heparin like molecul

79. which of following condition is including ehite infarct
a. Venous acclution
b. in loose tissue
c. in tisssue and double circulation
d. in tisssue previously congestion
e. in solid tissue

Jawab : E,slide

80. What is the most often cause of septic shock ?
a. Exotoxin
b. Endotoxin
c. Myocardial pump failure
d. Losss of blood volume
e. Hypoperfusion

Jawab : b, Robin

81. Subcutaneous edema is ussualy found in which of the following diease
a. Nephrotic syndrome
b. Acute respiratory distress msyndrome
c. Encepahlitis
d. HYpersensitivity reaction
e. Neoplasam aof the brain

Jawab : A,,pasti taulah ya knapa...=)

82. Which of the folloeing sentences refers to systemic edema due to prymay heart failure ?
a. Impaired venous return ]
b. Reduced plasama osmotic pressure
c. Lymphatic obstruction
d. Sodium retention
e. Arteriolar dilation

Jawab : A, Penjelasannya sama kayak no 75

83. What is the term for a hemmorhage that is sligtly than 3 mm ?
a. Petechiae
b. Echymosis
c. Purpura
d. HEmothorax
e. Hemorhagicc diathesis

Jawab : c,slide

84. Which of the following condition include into primary hypercoagulable state
a. Myocardial infection
b. Cxardiac failure
c. Acute leukimia
d. Antithrombotic III defeciency
e. Thrombotic thrombocytopenia


85. Proteinuria is condition that reflect impaired function of glomelurus. TYpe of protein that found in renal failure patient is.
a.alpha microglobulin
b. Albumin
c. Glycoprotein
d. Beta lipoprotein
e. a2 microglobulin

Jawab : Albumin, karena ukurannya besar jadi harusnya g ada di urin

86. This patient is asked to performed creatine clearence to determine his glomelurar fuction. THe specimrn that needed for creatine clearence to determine glomelurar function is
a. Timed urine
b. Morning urine
c. PP urine
d. 24 hour urine
e. Mid portion urine

Jawab : d,, dari catetan aku hehe...

87. Some substance can be found urine due to glomerular injury . Test to early detection glomelurar injury is..
a. Urine ionic strength
b. Cystacin C
c. Inulin clearence
d. Microalbuminuria
e. Fractional excretion sodium

88. The concentration of BUN is 15 mg/dl. The concentration urea is
a. 3 mg/dl
b. 5 mg/dl
c. 20 mg/dl
d. 30 mg/dl
e.42 mg/dl

Jawab : e.
Concentration urea : 2,8 * BUN jawabannya e

89. Cystin C is waste product that can be used as indice GFR . What is the process occur cystatcin C in proximal tubule
a. Reabsorption
b. Secretion
c. Excretion
d. Diffusion
e. Filtration

Jawab : A, Slide

90. Detection of the type pf substance present in urine can predict the progess of the dieases. What can be found in urine of most severe glomelurar damage?
a. Albuminaria
b. Hematuria
c. Glucosuria'
d. Ketonuria
e. Bilirubinuria

Jawab : A

91. The tubules are responsible for maintainaing normal plasma volume and osmolality . What is the term expressing the quantity of a substance eliminate in urine by the tubule ?
a. Free water clearence
b. Renal plasma flow
c. Filtration fraction
d. Fractional excretion
e. Fractional reabsorption

Jawab : D

92. What is the gold standard substance for measuring GFR
a. INulin
b. Creatinin
c. Urea nitrogen
d. Paraaminonipurate
e. Radioactive marker

jawab : a, catatan aklu juga...=)

93. What uf this renal function test affected by muscle fatigue
a. Cystin C
b. Creatinin level
c. BUN
d. Fractional excretion
e. Fractional reabsorption

Jawab : a, slide

94. The blood gas analysis result is :
pH : 7,25
pCo2 : 50 mmHg
pO2 : 88 mmHg
HCO3- : 20 mmol
What is BG interpretation ?
a. Hypoxemia
b. Metabolic acidosis
c. Metabolic alkalosis
d. Respiratory alkalosis
e. Respiratory acidosis

Jawab : E. kalau dilihat dari PH nya dia acidosis nah sekarang kita lait PCO2(40 plusminus 5) sama HCO3-(24 plus minus 2) nya . Klau kita liat nilai PCO2 nya tinggi nah kalau gitu berarti dia respiratory acidosis..

Soal FBS 9..

95.What is the anticoagulant used for BGA sample?
A.EDTA C.Citrate E.Fluoride
B.Heparin D.Oxalate
B.Rase2nyer r.. ga dapt di cari sumbernya dOngg!!ahaks.. oOppss.. Bentar.. kami udah jumpa.. yEay..!!Rupa2nya ada di slide Dr. Nadjwa Zamalek..Tajuknya Water,Electrolytes and Acid Base Metabolism.. Subtopic-Preparing the sample for BGA (Blood Gas Analysis) bukan Blood Group Antigen ya..!!

96.His electrolyte profile result is
H+ : 60mmol/l CI- : 103mEq/l
Na+ : 40mmol/l HCO3- :12mmol/l
K+ :5.0mmol/l PO3- :33mg/dl
Mg+ :3mEq/l
Please calculate the anion gap of the patient..
A.85mmol/l C.33mmol/l E.47mmol/l
B.30mmol/l D.90mmol/l

Ga tau dOng.. Dr. ga ajar..!! pulang awal.. nyontek aja…!! Dalam slide dr. nadjwa ada.. tajuk Water,Electrolytes and Acid Base Metabolism.. formulir nya ada..
Anion gap = Cation – Anion
e.g Anion gap =(Na+ + H+) minus (CI- + HCO3-)
unitnya ga sama.. jadi kami ga tau.. untuk yang tau.. nanti kasih tau ke kami ya??sms atau call aja.. jangan miscall ya.. nanti ibu Ana marah.. di kelas civics ga bisa misscall2.. kami ga layan..!!

97.The method to measure the free electrolyte concentration is..
A.Atomic absorption spectrophotometer
B. Ion-selective electrode
C.Refractometer
D.Flow cytometer
E.Flame photometer

B.Dari slide Dr. Nadjwa Zamalek..Tajuknya Water,Electrolytes and Acid Base Metabolism.. Subtopic-Methods of Measuring Electrolytes.. Dari slide di tulis In the past.. Sodium & potassium measurement – atomic absorption spectrophotometry & flame photometry, chloride-titration & colorimetry.. tapi bukannya untuk free electrolyte.. jadi kami fikir mungkin modern technology use nowadays yaitu ion-selective electrodes…!! Di refer ya?? Jangan ikut aja.. nanti sesat jalan..!! ahaks..

98.What is the dominant cation in intracellular fluid?
A.Sodium C.Calcium E.Ferum
B. Potassium D.Magnesium

B.Dari slide Dr. Nadjwa Zamalek..Tajuknya Water,Electrolytes and Acid Base Metabolism.. Subtopic-Electrolytes (Potassium) Sodium itu mayor cation di extracellular.. Jangan lupa baca ya.. Jangan malas..!! Ini soal famous gituuuuuuuuuuuu..!!


99.Increasing anion gap in DM patient is due to…
A.Uream C. Ketone E.Bicarbonate
B.Lactate D.Chloride
C.Dari slide Dr. Nadjwa Zamalek..Tajuknya Water,Electrolytes and Acid Base Metabolism.. Subtopic-Anion Gap.. Ditulis di slide ini Anion Gap akan increase bila ada diabetis KETOSIS,acidosis, starvation and uremia.. Ga pasti.. Buku Henry belum difotokopi.. Ga kenal gi mana rupanya Kang Henry itu.. Maaf ya.. Uang ga ada…!!!

100.Increase anion gap in marathon athlete is due to increase level of…
A.Phosphate C.Calcium E.Ketone
B.Bicarbonate D.Lactate

D.Dari slide Dr. Nadjwa Zamalek..Tajuknya Water,Electrolytes and Acid Base Metabolism.. Subtopic-Anion Gap.. Marathon menghasilkan Lactic acid.. Lactic acid = Lactate.. So, Anion gap akan increase sewaktu ACIDOSIS.. Ga percaya?? Cuba kamu marathon.. Keliling-keliling UNPAD aja.. Pasti banyak lactatenya ya??ayuh… di cobain doonnngg.. tp slepas EXAM aja ya..!!

101.Which is the major osmotically active substance?
A.Glucose C.Potassium E.Bicarbonate
B.Blood Urea Nitrogen D. Sodium

D.Dari slide Dr. Nadjwa Zamalek..Tajuknya Water,Electrolytes and Acid Base Metabolism.. Subtopic-Osmolal Gap.. Major osmotically active substance are Sodium,Glucose & Urea.. Sodium susunannya di atas.. jadi kami rasa Sodium.. Maaf ya Kang Henry kalau salah..!!ahaks

102.Which acid-base abnormality is the result of massive blood transfusion in thallasemia patient?
A.Metabolic Acidosis C.Respiratory Acidosis E.Hypoxemia
B. Metabolic Alkalosis D.Respiratory Alkalosis

B.Dari slide Dr. Nadjwa Zamalek..Tajuknya Water,Electrolytes and Acid Base Metabolism.. Subtopic-Metabolic Alkalosis.. Ditulis di slide…Metabolic Alkalosis-Prolonged vomiting, diuretic therapy,massive blood transfusion…

103. The most common sites of hematogenous metastasis are….
A.Brain & Kidney C.Liver & Kidney E.Lung & Brain
B.Bone & Brain D. Lung & Liver

D.Waduh2.. capek kami mencarinya.. stelah stiap lembar page kami selongkari akhiiirnya… kami ketemui di Buku Pathologic Basis Of Disease (Robin & Cotran).. page 280-281.. Tajuk NEOPLASIA ya..! di bagian hematogenous spread.. di baca ya?? Jangan malu2.. nanti Dr. Lasma sama Dr. Ismet sedih kalo kamu ga baca..!! kalo mau lebih ngerti bikin mapping aja.. kan gampang…!!ahaks..


104.Forms a complex with cyclin E in late G1, which is involve in the G1/S transition…
A.CDK 4 C.CDK 1 E.CDK3
B. CDK 2 D.CDK 6
Ini ma.. dulu waktu FBS3 juga ada… hehehehe… tapi skarang di tajuk NEOPLASIA.. Buku Pathologic Basis Of Disease (Robin & Cotran).. waduh2.. tajuk ini baaaaannnyyyaaaakk bangat dooonngg… capek otak aku..!! sampe tertidur aku.. berbunyi-bunyi dengkur.. (snoring)ahaks.. kamu refer di page 290-291.. di bagian ada figure kecil di bawah sama di page sebelahnya ya..!!!

105.Gastric lymphoma that much evident linking gastric infection with…
A.HTLV-1
B.Treponema Pallidum
C. Helicobacter Pylori
D.Clostridium Tetani
E.Human Papilloma Virus

C.Ini juga di tajuk NEOPLASIA..Masih di Buku Pathologic Basis Of Disease (Robin & Cotran) di subtopic-Helicobacter Pylori.. Pagenya 327.. Ini juga sewaktu FBS 2.. Case no. 4.. Mr. Dodi Naludi.. yg sakit Duodenal Ulcer Disease itu.. Masih ingat..?? ksian ama dia ya?? ahaks..


106.Which of the following cancer that is uncommon in children below 15 years old?
A.Wilm’s Tumor C.Neuroblastoma E. Melanoma
B.Retinoblastoma D.Leukemia

E.Ini juga di tajuk NEOPLASIA.. Buku Pathologic Basis Of Disease (Robin & Cotran).. page 284.. di situ di listkan di bagian kanan di sebelah atas.. ditulis cancer yang common during infancy and childhood.. smuanya ada tapi melanoma aja yang ga ada..!! jadi itulah jawabannya dooonngg.. gampang aja ya.. itu ma kalo ada robin & co$tran waktu UAS (ujian akhir semester)…!! Jadi bawak aja basis pathologynya.. tapi ditinggal in di luar aja ya..!! ahaks..

107.Which of the following gene act as anti-apoptosis?
A.RAS C. Bcl-2 E.WT-1
B.BAX D.RB

C.Ini ma.. di tajuk cell injury.. Buku Pathologic Basis Of Disease (Robin & Cotran).. di bagian apoptosis.. jawabannya di bagian mechanism of apoptosis.. di extrinsic pathway(DD pathway) atau di intrinsic pathway(mitochondrial pathway)?CUBA TEKA..!! Fikir dula ya.. 1 menit masa kami beri.. kami mau makan dulu.. mau makan ayam laos.. udah lapar doonng.. pokoknya seda’ sekali.. istimewa untuk sahabat.. 5 ribu aja..
UdaH?? Wah.. cepat benar.. yA.. tepat sekali.. jawabannya intrinsic pathway.. di page 29.. katanya the two anti-apoptotic one is the Bcl-2 and Bcl-X.. jadi.. jawabannya udah semestinya C..!!

Untuk anak2 KPBI.. jangan lupa ya.. Dr. Lasma udah sering kasih tau tentang apoptosis.. di bikn mapping.. jgn di lupa.. kasihan sama ibu kita.. Dr. Lasma.. udah capek.. Yuk.. beli Teh botol sosro untuk Dr. Lasma yuk..!! :p

p/s: untuk semua.. selamat menempuh final exam 1st year nanti ye..!! buat elok2.. ingatlah org yg tsayang..!! smoga smua bjaya & jumpa lagi bulan 9 ni di 2nd year.. InsyaALLAH…!!

“ujian adalah tarbiah daripada ALLAH.. apakah kitakan sabar ataupun sebaliknya… kesenangan yang datang selepas kesusahan semuanya adalah nikmat dari tuhan…”

YANG CAPEK,
_JAMALUDDIN & ATHRASH_
KPBI 07/08
SUPERSTAR

108. Malignant epithelial tumors with grandular growth pattern called as :
Ans: Adenocarcinoma (Slide95, Neoplasia Dr Ismet)

109. The most common paraneoplastic syndrome is:
Ans: Hypercalcemia (Pg333, Robbins&Cotran)

110. Abberant mass with mature differentiation but disorganized, is called:
Ans: Hamartoma (Slide100, Neoplasia Dr Ismet)

111. Sarcoma arising from or resembling smooth muscle cells is: Ans: Leiomyosarcoma (Slide95, Neoplasia Dr Ismet)

112. The extent to which tumor cells resemble comparable normal cells is called:
Ans: Differentiation (Pg272, Robbins&Cotran)

113. Which of the following tumors that made up of a variety of parenchymal cell type
representative of more than one germ layers?
Ans: Teratoma (Slide97, Neoplasia Dr Ismet)

114. Darkly stained nuclei that frequently contain prominent nucleoli is called:
Ans: Hyperchromasia(Slide230, Neoplasia Dr Ismet)

115. Gene that promotes autonomous cell growth in cancer cells is called:
Ans: Oncogene (Pg292, Robbins&Cotran)

116. Which of the following gene is included in tumor suppressor gene?
Ans: APC Gene (Pg304, Robbins&Cotran)

117. What is the cause of over expression of E6 and E7 proteins?
Ans: HPV (Pg324, Robbins&Cotran)

118. Which of the following virus will cause over expression of LMP-1 protein?
Ans: EBV (Pg325, Robbins&Cotran)

119. What molecular changing happened during transformation of intermediate
adenoma to late adenoma in colorectal cancer?
Ans: Loss of tumor suppression on chromosome 18q (Slide93, Neoplasia
Standarisasi)

120. Which of the following glycoprotein that acts as glues between epithelial cells?
Ans: Cadherins (Pg305, Robbins&Costran)

121. What mutation is found in 20% of familial melanomas?
Ans: The INK4a/ARF (Pg305, Robbins&Costran)

122. Two mutations of the RB locus on chromosome 13q14 lead to neoplastic proliferation is pathogenesis of :
A. Cooorectal carcinoma
B. Thyroid carcinoma
C. Retinoblastoma
D. Wilm’s tumor
E. Hepatocellular carcinoma
Ans: C. Retinoblastoma (Robbins & Cotran page 299)

123. According to the term of adenoma, which organ could not show the tumor?
A. Small bowel
B. BladderC. Large bowel
D. Esophagus
E. Hypophyse
Ans: D. Esophagus (Robbins & Cotran page 270)

124. An 8-year-old female can bend her thumb back to the forearm. She can pull her skin out from her abdomen about 8 cm and when her skin is cut, difficult to repair. What is your diagnosis?
A. Down syndrome
B. Tay-Sachs diseaseC. Ehlers-Danlos syndrome
D. Turner syndrome
E. Gaucher syndrome
Ans: C. Ehlers-Danlos syndrome (Robbins & Cotran page 155)

For question number 125 & 126, refer to the scenario below:
A 25-year-old female with amenorrhea is 146 cm tall and is found on physical examination to have a webbed neck. An abdominal magnetic resonance imaging shows streak ovaries that are small, long and thin.

125. These features are classic for which disease?
A. Down syndrome
B. Tay-Sachs diseaseC. Ehlers-Danlos syndrome
D. Turner syndrome
E. Gaucher syndrome
Ans: D. Turner syndrome (Robbins & Cotran page 180)

126. Which of the following chromosomal abnormalities is most likely to present?
A. 45,X
B. 47,XX
C. 47,XY
D.69,XXY
E. 47,XXY
Ans: A. 45, X (RobbinS & Cotran page 179)

For questions number 127 and 128, refer to the scenario below:
A fetus is delivered stillborn at 19weeks gestation. The macerated fetus shows marked hydrops fetalis. There is a large posterior cystic hygroma of the neck. Autopsy reveals internal anomalies, including aortic coartation and a horseshoe kidney

127. Which of the following disease is most likely to develop in this fetus?
A. Down syndrome
B. Tay-Sachs diseaseC. Ehlers-Danlos syndrome
D. Turner syndrome
E. Gaucher syndrome
Ans: B. Turner syndrome (Robbins & Cotran page 179, Genetic Disorder Slide page 54)


128. Which of the following is most likely to be found on the chromosome analysis of fetal cells?
A. 45,X
B. 47,XX
C. 47,XY
D.69,XXY
E. 47,XXY
Ans: A. 45, X (Robbins & Cotran page 179, Genetic Disorder Slide page 53)

129. A 25 year old male has a work up for infertility and is found to have oligosperma. Physical examination findings include bilateral gynecomastia, reduced testicular size, and reduced body hair. He has a distinctive body habitus, increase length between soles and the pubic bone, and also an eunuchoid body with abnormally long legs. Which of the following karotypes is most likely to be found on chromosome analysis of this person?
A. 45,X
B. 47,XX
C. 47,XY
D.69,XXY
E. 47,XXY
Ans: E. 47,XXY - Klinefelter syndrome (Robbins & Cotran page 179, Genetic Disorder Slide page 52)

For questions number 130 until 132, refer to the scenario below:
Bombi, a 10 year old boy, although mentally retarded, is able to carry out activities of daily living, including feeding and dressing himself. On physical examination, he has brachycephaly and oblique alpebral fissures with prominent epicanthal folds. On palm of each hand is seen transverse crease. On auscultation of the chest there is a gradeII systolic murmur. The doctor diagnose Bombi’s condition is Down Syndrome.

130. In which category is Bombi’s genetic disorder included?
A. Cytogenic disorder involving autosomes
B. Cytogenic disorder involving sex chromosome
C. Multifactorial inheritance
D. Mendelian disorder
E. Atypical pattern ofinheritance
Ans: A. Cytogenic disorder involving autosomes (Robbins & Cotran page 175, Genetic Disorder Slide page 48)

131.If Bombi’s doctor need to perform genetic analysis or karyotyping, which of the following tools can be used?
A. FISH
B. PCR
C. Southern blot
D. All of the above
E. None of the above
Ans: C. Southern blot

132. If the karyotyping was done, the most likely karyotype of Bombi’s disorder is:

A. Trisomy 12 type
B. Trisomy 13 type
C. Trisomy 18 type
D. Trisomy 21 type
E. Tetrasomy

Ans: D. Trisomy 21 type
In the question given state that "The doctor diagnose Bombi’s condition is Down Syndrome.", so, if refer to
Robbins and Cotran page 175, Down Syndrome is Trisomy 21.=)

133. A 25-year-old male has a work up for infertility and is found to have oligospermia. Physical examination
findings include bilateral gynecomastia, reduced testicular size and reduced body hair. He has a distinctive body
habitus; increase length between soles and the pubic bone, and also an eunuchoid body with abnormally long legs.
These features are characteristic of which disorder?

A. Down syndrome
B. Klinefelter syndrome
C. Turner syndrome
D. Hermaphroditism
E. Pseudohermaphroditism

Ans: B. Klinefelter syndrome
All the characteristics given in the question fit the statement in the characteristics of Klinefelter syndrome in the Robbins and Cotran page 179."Most patient have a distinctive body habitus with an increase in length between the sole and the pubic bone, characteristic are eunuchoid body habitus with abnormally long legs; small atrophic testes often associated with a small penis; lack of such secondary male as deep voice beard, and male distribution of pubic hair. gynecomastia may be present."=)

134. Which of the following statement is NOT suitable for autosomal recessive disorder?

A. Occurs only when both alleles at a given locus are mutants
B. The trait usually affect the parents
C. Siblings may show the disease
D. Onset is frequently early in life
E. Occurs when one alleles at a given locus are mutants

Ans: confuse between B. or E.
Base on Robbins and Cotran page 151: Autosomal recessive inheritance is the single largest category of mendelion disorders result "only when both" alleles at a given locus are mutants, such disorder are characterized by the following features: (1) The trait "does not" usually affect the parents, but siblings may show the disease;....
For me,both answers are wrong...or anyone can identify which is the MOST NOT SUITABLE answer??=p

135. Which of the following disorders is the disease of autosomal recessive?

A. Marfan syndrome
B. Lysosomal storage disease
C. Neurofibromatosis
D. Ehlers-Danlos syndrome
E. Down syndrome

Ans: B. Lysosomal storage disease
Please refer to Table 5-2 in Robbins and Cotran page 151...=)

136. Direct gene diagnosis is a approach apply to diagnostic in genetic disease by recombinant DNA technology which involved:

A. Detection of mutant gene
B. Detection of linkage of the disease with a harmless "marker gene"
C. Immunoflourescent
D. Immunohistochemistry
E. Dissemination of mutant gene

Ans: A. Detection of mutant gene
Refer Robbins and Cotran page 188: Direct gene diagnosis..=)

137. Which of the following statement is suitable for mutation?

A. Mutation is a temporary change in the DNA
B. Mutation that affect germ cell are translated to progeny
C. Mutation that arise in somatic cells cause hereditary disease
D. Chromosome mutations involved loss or gain of whole chromosome
E. Genome mutation give rise to visible structural changes in the chromosome

Ans: B. Mutation that affect germ cell are translated to progeny
Base on Robbins and Cotran page 147... Mutation is a 'permanent' change in the DNA. Mutation that arise in somatic cells 'understandably do not' cause hereditary disease. 'Genome' mutations involved loss or gain of whole chromosome. 'Chromosome' mutation give rise to visible structural changes in the chromosome.

138. Which of the following statement is INCORRECT?

A. Mutation can interfere with protein synthesis at various level
B. Transcription may be suppressed with gene deletion and point mutation involving promoter
sequences
C. Translation is affected if a stop codon is created within an exon
D. Some point mutation may lead to the formation of an abnormal protein without impairing any step in protein sequences
E. Less extreme genotyping errors never lead to full embryogenic development and live birth

Ans: E. Less extreme genotyping errors never lead to full embryogenic development and live birth
Base on Robbins and Cotran page 149 (To summerize,....), all the answers from A. to D. is correct.=)

139. The result of CSF examination:
WBC 80 cells/µL
Differential counting: lymphocyte 5, monocyte 5, neutrophil 80
Protein 110 mg/dL
Glucose 25 mg/dL

What is the most etiology of meningitis in this patient?

A. Inflammatory process
B. Tuberculous meningitis
C. Trauma
D. Bacterial meningitis
E. Viral meningitis

Ans: D. Bacterial meningitis
The most distinctive reasons why the answer is D. is because neutrophil present in the CSF exam. Please check it out from Dr.Nadjwa's lecture slides on Stool and Other Body Fluid Analysis: Cerebrospinal Fluid=p

140. The CSF specimen is ordinarily divided into several tubes. Which tube is used for microbiologic examination at LCS examination?

A. 1st tube
B. 2nd tube
C. 3rd tube
D. 4th tube
E. 5th tube

Ans: B. 2nd tube
Refer Dr.Nadjwa's lecture slides on Stool and Other Body Fluid Analysis: Cerebrospinal Fluid
Specimen Collection
- Collected in 3 sterile tubes:
1. Tube 1: chemical & serologic test
2. Tube 2: microbiology
3. Tube 3: cell count & differential

141. The condition that causes increasing level of protein in patient with meningitis is:

A. Increase permeability of blood brain barrier
B. Decrease resorption at arachnoid villi
C. Mechanical obstruction
D. Increase intrathecal immunoglobulin synthesis
E. Increase hydrostatic pressure

Ans: A. Increase permeability of blood brain barrier
Refer Dr.Nadjwa's lecture slides on Stool and Other Body Fluid Analysis: Cerebrospinal Fluid
Chemical Analysis
- elevated CSF protein
1. Increase permeability of blood brain barrier (meningitis, hemorrhage)
2. Decrease resorption at arachnoid villi
3. Mechanical obstruction (tumor)
4. Increase intrathecal immunoglobulin synthesis (Guillain-Barre syndrome, multiple sclerosis)

142. Chemical analysis in pleural fluid includes amylase level.Increase level of amylase in pleural fluid suggest :

A. Pancreatitis
B. Tuberculous infection
C. Congestive heart failure
D. Bacterial infection
E. Viral infection
Answer : A
Reference : “Henry’s Clinical Diagnosis” page 441

143. Which cell will increase in pleural fluid with viral infection ?

A. Mesothelial cell
B. Neutrophil
C. Eosinophil
D. Lymphocyte
E. Basophil
Answer : D
Reference : slide “ Stool and Other Body Fluid analysis”

144. Which staining is needed to see leucocytes in microscopic examination of feces?

A. Sudan III
B. Eosin
C. Nacl
D. Methylene blue
E. Giemsa
Answer : D
Reference : slide “ Stool and Other Body Fluid analysis”

145. Which cell increase in helminthes infection with differential counting of white blood cell ?

A. Neutrophil
B. Lymphocyte
C. Basophil
D. Eosinophil
E. Monocyte
Answer : D
Reference : slide “ Stool and Other Body Fluid analysis”

146. Substance that could give FALSE negative result of fecal occult blood test is :

A. Aspirin
B. Red meat
C. Turnips
D. Vitamin C
E. Cimetidin
Answer : D
Reference : slide “ Stool and Other Body Fluid analysis”

147. Which anticoagulant is needed for cell count in synovial fluid examination ?

A. Li Heparin
B. Na heparin
C. K2 EDTA
D. Oxalate
E. Citrate
Answer : C
Reference : slide “ Stool and Other Body Fluid analysis”

148. Ali, 35 year-old man,tall and skinny,working as a building labor,brought by his family to the emergency department of Dr.Hasan Sadikin Hospital because of unconsiousness with convulsion.After some physical examination, the doctor decided to perform lumbar puncture.
Where is the common location of this procedure ?

A. between Th 3- Th 4
B. between Th 4- Th 5
C. between Th 12 – L 1
D. between L 2- L 3
E. between L 3- L 4
Answer : E
Reference : slide “ Stool and Other Body Fluid analysis”

149. During lumbar puncture, the doctor found that the opening pressure is 210mmH2O
( NR: 90-180 mmH2O ). What is your conclusion about this condition ?

A. Doctor should stop the procedure
B. Doctor can continue the procedure
C. The amount of CSF can be withdrawn maximal only 2 ml
D. The amount of CSF can be withdrawn maximal only 3 ml
E. The amount of CSF can be withdrawn maximal only 4 ml
Answer : C
Reference : “Henry’s Clinical Diagnosis” page 427

150. Gross examination of Ali’s CFS showed clot formation. What is your mostly possible diagnosis ?

A. Meningitis Tuberculosis
B. Subarachnoid hemorrhage
C. Meningitis viral
D. Meningioma
E. Meningitis fungal
Answer : A
Reference : slide “ Stool and Other Body Fluid analysis”

151. Fariz, 24 year-old man, came to see his family doctor with painful, swelling and redness of both of his metacarpal joints.
For further analysis of Fariz’s synovial fluid, what procedure should be performed by his doctor ?

A. Thoracentesis
B. Arthrocentesis
C. Craniocentesis
D. Pericardiocentesis
E. Peritoneocentesis
Answer : B
Reference : slide “ Stool and Other Body Fluid analysis”

152. The doctor suspected that Fariz had Rheumatoid Arthritis, an inflammatory disease of joints. What is expected color of his synovial fluid ?

A. Straw coloured
B. Yellow
C. Brown
D. Green
E. Red
Answer : A
Reference : slide “ Stool and Other Body Fluid analysis”

153. Microscopic examination of Fariz’s synovial fluid revealed number of cells are 250/μL. What cells are expected to be increased ?

A. Basophil
B. Neutrophil
C. Eosinophil
D. Monocyte
E. Lymphocyte
Answer : B
Reference : slide “ Stool and Other Body Fluid analysis”

154. Mamat,a 42-year old skinny man, reffered to Department of Interna Medicine pf Dr. Hassan Sadikin Hospital because of difficulty in breathing.He had history of chronic cough with episodes of bloody sputum. X-ray examination showed pleural effusion in his right lung.What is the possible pathophysiology of this effusion?
Ans: From slide (Lecture Stool and Other Body Fluid Analysis), bloody sputum is exudates. Thus, possible pathophysiology is increased capillary permeability.


155. The appearance of pleural fluid is turbid. What cell count or chemical analysis result could be expected?
Ans: From the slide (Lecture Stool and Other Body Fluid Analysis),.Under gross examination, if turbid, it’s exudates. Exudates: Protein > 3g/dL, Glucose=serum, LDH PF/S ratio > 0.6, >200 IU/L, pH >/<7.3,> 1000/µL

156. Mr. M doesn’t have a vehicle, he used angkot (Public Transportation) and had to walk around 750m to ankot terminal and angkot stop around 750m from the hospital. What parameter in urinalysis could be affected by his activity?
Ans: From Henry (pg 376), glucose may appear in urine at different bood glucose level. Thus, glucose is affected by Mr. M’s activity.(not sure)

157. Mr. L, 24-year-old, heavy smoker, came to laboratory hospital for medical check up. What laboratory parameters is expected to be right?
Ans:Increase: carboxyHb, plasma catecholamines, cortisol, free fatty acid, neutrophil, monocyte.Decrease: Eosinophil. From slide (Clinical Laboratory)

158. MM, a 16 years old girl goes directly to laboratory hospital after playing tennis, for medical check up. What laboratory parameter expected to be high/abnormal?
Ans: Initial decrease followed by an increase in : free fatty acid, alanine, lactate. Elevated: CK, AST, LD. Activate coagulation, fibrinolysis and platelet. From slide (Clinical Laboratory)

159. Fecal occult blood is one of he test which widely used as a screening for colorectal cancer. What meals should be avoided to gain an accurate results?
Ans: Meat and Fat. Fatà Potassium, triglyceride, alkaline phosphatase. Meatà urea, ammonia, urate .From slide (Clinical Laboratory)

160. Mrs. NZD who ate a lot of meat daily, performed medical check up. What laboratory parameters ia expected to be high?
Ans: Ammonia: Meatà urea, ammonia, urate .From slide (Clinical Laboratory)

161. A 5 years old boy diagnosed by his doctor as having Acute Lymphoblastic Leukemia. In order to confirm his diagnoses and to predict the prognosis, the doctor suggested to performed immunophenotyping. Wht is the method used to analyze this parameter?
Ans: From Henry page 67, under Common Flow Cytometers in Use, Fluorochromes with a diversity of excitation and emission wavelengths and their conjugation to monoclomal and antibodies have contributed to the widespread application of flow cytometry to immunophenotyping in leukemia, lymphoma, and monitoring of immune status. Thus,

For question 162-164, refer to scenario below:
Mr. H, 56 years old man was brought to the emergency department of Dr. Hassan Sadikin Hospital with acute left chest pain. Doctor suspect that Mr.H has an acute myocardial infarction, whereas one of its risk factor is hypercholesterolemia.

162. What is the method used to measure this risk factors?
Ans: Spectrophotometer. From slide (Lecture Principles of Instrumentation)

163. W hat is the basic principal of measurement?
Ans: Beer-Lembert Law. From slide (Lecture Principles of Instrumentation)

164. This basic principle can be applied only in standard condition, such as:
Ans:

165. Laboratory results show that LDH-5 of Mr H is very high. LDH is one of the 5 isoenzyme of LDH. What method is used o measure this parameters?
Ans:Electrophoresis. From slide (Lecture Principles of Instrumentation)

Soal FBS 9 no. 23-46

23. The doctor suspected Riri had an urinary tract infection, and gave her Bactrim for 3 days. After 3 days, this girl still had that complaint, then the doctor change the antibiotic with ciprofloxacin. What is the purpose of laboratory test had been performed by the doctor?

A. Confirming diagnosis

B. Rejecting diagnosis

C. Case finding

D. Monitoring therapy

E. Predicting prognosis

Jawaban: D

Pembahasan: Slide “The Clinical Laboratory”

23. Rahmat, 20-year-old, came to primary health care with moderate fever, sore throat, cough with mucopurulent sputum. Laboratory results: WBC count = 14.000/L (NR: 4.000-10.000/L), and 80% Neutrophil (PMN) in WBC differential count. What is the most possible infectious agent in this patient?

A. Prion

B. Virus

C.Bacteria

D. Fungus

E. Parasite

Jawaban: C

Pembahasan: Soalnya WBC naik dengan neutrophil yang dominant.

23. A 23-year-old lady came to primary health care (Puskesmas) with a complaint of restlessness since a month ago. She also stated that she felt very dizzy if she stands up directly from sitting. This lady has 4 children and delivered almost every year since she was married at 18 years old. Because she was poor, her daily diet usually consists of steam rice with slated fish and small amount of vegetables. Laboratory result revealed: Hgb = 8 g/dl (NR: 12-16 g/dl); Hct = 28% (NR: 37-47%); RBC count = 4x10⁶/L (NR: 4.2-5.4x10⁶/L). What is the most common etiology of this lady’s condition?

A. Iron deficiency anemia

B. Thalassemia

C. Anemia of chronic disease

D. Familial ovalocytosis

E. Congenital spherocytosis

Jawaban: A

Pembahasan: Hgb naik, Hct naik, RBC naik itu menunjukkan si lady mengalami anemia. Kalau dihitung MCV nya hasilnya 70, berarti anemia microcytic. Nah, anemia microcytic itu bisa karena iron deficiency atau karena chronic disease. Si lady ini kan g ada tanda2 chronic disease, jd mungkin dia terkena iron deficiency anemia akibat sering melahirkan dan asupan zat besi dari makanan jg kurang.

23. Mr. R, 35-year-old man, was bring to the emergency department of dr. Hasan Sadikin hospital because difficulty in breathing. What laboratory parameter needed to be evaluated, which available as point of care test?

A. Liver enzymes

B. Blood gas analysis

C. Urinalysis

D. Blood cholesterol level

E. Uric acid level

Jawaban: B

Pembahasan: pasien ini kan susah bernapas, jadi lab parameter yg paling cocok kykny BGA supaya bisa tau bagaimana kadar CO2 ,O2 di darahnya saat ini.

23. As the head of blood transfusion unit, you need to decide which test will be used to screen HIV in donor’s blood. Which of the following test is met your demand?

A. Test I : sensitivity = 99.8%; specificity = 89%

B. Test II : sensitivity = 99.5%; specificity = 92%

C. Test III : sensitivity = 99.3%; specificity = 90%

D. Test IV : sensitivity = 99.8%; specificity = 91%

E. Test V : sensitivity = 99.6%; specificity = 93%

Jawaban:

Pembahasan:

23. Which of the following laboratory parameter is evaluated in hematology subdivision?

A. IgG and IgM Dengue

B. Triglyceride

C. Widal test

D. Hematocrit

E. Urobilinogen

Jawaban: D

Pembahasan: Slide “Basic Examination of Blood”

23. Which of the following test is used to screen the donor?

A. WBC count

B. Hepatitis B antigen

C. Erythrocyte sedimentation rate

D. IgG and IgM dengue

E. RDW

Jawaban: B

Pembahasan: Hepatitis B antigen test termasuk dalam salah satu Transfusion-transmitted disease testing.

23. Which of the following test can be used as a screening but also as a confirmatory test?

A. Blood glucose level

B. Serum iron

C. Blood cholesterol level

D. Urinary protein

E. Urinary cast

Jawaban:

Pembahasan:

23. Riri, 3-year-old girl, brought to family physician with a chief complaint of moderate fever and dysuria. What laboratory test should be suggested by the doctor?

A. Blood gas analysis

B. Urinalysis

C. Stool examination

D. Liver function test

E. Kidney function test

Jawaban: B

Pembahasan: Kalau pasien mengalami dysuria, ini bisa disebabkan karena ada iritasi atau ada infeksi di urinary tract. Jd , lab test yg biasa dilakukan adalah urinalysis, dilihat apakah urinnya mengandung darah atau ada bakteri.

23. A 18-year-old boy came to general practitioner with a complaint of moderate fever, nausea, abdominal discomfort, yellowish skin, and dark color urine. What parameter in urinalysis expected to be abnormal?

A. pH

B. Protein

C. Glucose

D. Ketone

E. Bilirubin

Jawaban: E

Pembahasan: Kalau ada kerusakan di liver maka bilirubin di urin akan meningkat.

23. This patient’s urinalysis was performed in private laboratory. What is the best specimen for this laboratory test?

A. Fresh voided morning urine

B. Random urine

C. 10 hrs fasting urine

D. 12 hrs urine collected

E. 24 hrs urine collected

Jawaban: A

Pembahasan: Fresh voided morning urin digunakan untuk menentukan (+)/(-) suatu zat di urin. Karena urin jenis ini memiliki optimal concentrate.

23. Mr. M, 40-year-old man, went to laboratory hospital for medical check up. Both of his parents are diabetics. What parameter expected to be abnormal in his urinalysis?

A. pH

B. Protein

C. Glucose

D. Bilirubin

E. Urobilinogen

Jawaban: C

Pembahasan: jelaslah y….

23. Mr. K, 70-year-old man, diagnosed by the doctor as coma hepaticum due to late stage of liver cancer. He had a big ascites and yellowish skin. How to get the urine for urinalysis for this condition?

A. By suprapubic puncture

B. By chatetherization

C. By collecting midstream urine

D. By collecting fresh voided morning urine

E. By collecting 2 hrs urine

Jawaban: D

Pembahasan: sama kyk no. 33

23. Mr. K with liver carcinoma. What urinalysis parameter expected to be abnormal in this patient?

A. Protein

B. Glucose

C. Ketone

D. Bilirubin

E. Nitrit

Jawaban: D

Pembahasan: sama kyk no. 32

23. RBCs within the urine can come from any point along the urinary tract. Dysmorphic RBCs are often a sign of……..

A. Kidney disease

B. Uretheral disease

C. Glomerular disease

D. Tubular disease

E. Bladder disease

Jawaban: C

Pembahasan: henry ed 20 hal 389  RBCs with cellular protrusions or fragmentation are termed dysmorphic, and some authors have suggested that their presence in urine samples is strongly suggestive of renal glomerular bleeding.

23. Proteinuria more than 4 g/day is commonly seen in……….

A. Nephrotic syndrome

B. Acute glomerulonephritis

C. Chronic glomerulonephritis

D. Acute pyelonephritis

E. Chronic renal failure

Jawaban: A

Pembahasan: henry ed 20 hal 374

23. What is the most common observed casts in the urine?

A. Hyaline casts

B. Waxy casts

C. Erythrocyte casts

D. Leukocyte casts

E. Renal tubular epithelial cell casts

Jawaban: A

Pembahasan: henry ed 20 hal 391

23. S, 3-year-old girl was brought by her mother to their family physician with a chief complaint of dysuria. What urinalysis parameter is expected to be abnormal?

A. Glucose

B. Bilirubin

C. Urobilinogen

D. Specific gravity

E. Nitrite

Jawaban: E

Pembahasan: kemungkinan dysuria ny disebabkan oleh infeksi bakteri di urinary tract. Dari pilihan di atas, yg di pake bwt ngetes ada infeksi bakteri ato g adalah Nitrite.

23. The stool of this patient is pale. Acholic stool that can be found in massive diarrhea is due to decrease level of:

A. Urobilin

B. Urobilinogen

C. Stercobilinogen

D. Stercobilinogen

E. Indirect bilirubin

Jawaban: C & D

Pembahasan: slide “Liver Func. Test”

23. The liver is the site of most plasma protein. Which test can be use to determine the synthetic function of the liver?

A. Globulin concentration

B. Prothrombin time

C. Alpha feto protein

D. Total bilirubin serum

E. AST

Jawaban: B

Pembahasan: slide “Liver Func. Test”

23. One test to determine liver injury is De Ritis ratio. It is the ratio of:

A. GGT and glutamic oxaloacetic transaminase

B. ALP and LDH

C. AST and ALT

D. ALT and ALP

E. AST and LDH

Jawaban: C

Pembahasan: slide “Liver Func. Test”

23. The enzyme that significantly increase in obstructive process in the liver is:

A. AST

B. ALT

C. LDH

D. ALP

E. GGT

Jawaban: E

Pembahasan: henry ed 20 hal 268-269  disebutkan bahwa ALP dan GGT meningkat karena obstructive process. GGT itu more sensitive tp less specific dibanding ALP dan menigkat pd 80-95% pasien dgn liver disease.

23. Which test is the screening test for hepatocellular carcinoma?

A. LDH

B. De ritis ratio

C. Alpha feto protein

D. ALP

E. Perinuclear antineutrophil cytoplasmic antibody

Jawaban: C

Pembahasan: slide “Liver Func. Test”

23. What is the congenital disorder of bilirubin metabolism that cause by reduced activity of bilirubin-UDP-glucoronyl transferase?

A. Gilbert’s syndrome

B. Crigler-Najjar syndrome

C. Dubin-Johnson syndrome

D. Rotor syndrome

E. Hemolytic disease of the newborn

Jawaban: A

Pembahasan: slide “Liver Func. Test”

Tolong di cek lg kebenarannya.

Kalo ada yg salah mohon diperbaiki ya…

Maaf, g bisa kejawab smua…jd bagi temen2 yg tau jwbn no 27 & 30 tolong di post-in ya…makasih

ralat soal2 accessory glandof female no

no 14 seharusnya begini:

14. Which one is NOT secrete of prostate?

1. Citric acid

2. Acid phosphatase

3. Proteolytic enzymes

4. Prostaglandin
   

5. Seminalplasmin

jawab: D/4

sorry ya tmn2

accessory gland of male

1. Which one is the right step for sperm from testes to penis?

1. Duct of the testes → epidydimis → ejaculatory duct → ductus deferent → urethra

2. Duct of the testes → ductus deferent → epidydimis → ejaculatory duct → urethra

3. Epidydimis → duct of the testes → ductus deferent → urethra → ejaculatory duct

4. Duct of the testes → epidydimis → ductus deferent → ejaculatory duct → urethra

5. Epidydimis → duct of the testes → ductus afferent → urethra → ejaculatory duct

2. Which one is the right step of duct of the testes?

1. Tubuli recti → rete testis → efferent duct

2. Rete testis → efferent duct → tubuli recti

3. Rete testis → tubuli recti → efferent duct

4. Tubuli recti → efferent duct → rete testis

5. Efferent duct → rete testis → tubuli recti

3. Where is the site of sperm maturation?

1. Tubulus seminiferous contortus

2. Sertoli cells

3. Epidydimis

4. Tubulus seminiferous rectus

5. Ductus deferent

4. Where is the sperm stored?

1. Tubulus seminiferous contortus

2. Sertoli cells

3. Epidydimis

4. Tubulus seminiferous rectus

5. Ductus deferent

5. Which one is the right muscle in ductus deferent from inner to outer?

1. Longitudinal, circular

2. Longitudinal, circular, longitudinal

3. Circular, longitudinal

4. Circular, longitudinal, circular

5. Circular only

6. Where does the ejaculatory duct terminate?

1. Urethra

2. Seminal vesicle

3. Ductus deferent

4. Prostatic urethra

5. Membranous urethra

7. What is the function of ejaculatory duct?

1. Store sperm

2. Eject seminal vesicle secretion

3. Eject sperm

4. Eject sperm and seminal vesicle secretion

5. Store and eject sperm

8. Which one is the right step of urethra?

1. Membranous urethra → prostatic urethra → spongy urethra

2. Membranous urethra → prostatic urethra → penile urethra

3. Prostatic urethra → membranous urethra → penile urethra

4. Membranous urethra → penile urethra → prostatic urethra

5. Prostatic urethra → penile urethra → membranous urethra

9. Which one is NOT the accessory sex gland of male?

1. Cowper’s glands

2. Prostate

3. Bulbourethral glands

4. Paraurethral glands

5. Seminal vesicles

10. What are secretes of seminal vesicles?

1. Alkaline, fructose, prostaglandins, clotting protein

2. Alkaline, fructose, clotting protein

3. Alkaline, fructose, seminalplasmin, clotting protein

4. Citric acid, fructose, seminalplasmin, clotting protein

5. Citric acid, fructose, seminalplasmin

11. What is the function of fructose in semen?

1. Neutralize the acidic environment

2. Breakdown the clotting protein

3. ATP production of sperm

4. Antibiotic

5. Protect the sperm

12. What is the function of prostaglandin in semen?

1. Sperm motility

2. Stimulate skeletal muscle contraction within female

3. Stimulate skeletal mescle contraction within male

4. Semen coagulation

5. Allergic reaction

13. Where is the position of prostate?

1. Superior to urinary bladder

2. Inferior to Cowper’s glands

3. Inferior to prostatic urethra

4. Surrounds the Cowper’s glands

5. Surrounds the prostatic urethra

14. Which one is NOT secrete of prostate?

1. Citric acid

2. Acid phosphatase

3. Proteolytic enzymes

4. Prostate-specific antigen

5. Seminalplasmin

15. Where does the duct of Cowper’s glands open into?

1. Spongy urethra

2. Membranous urethra

3. Prostatic urethra

4. Prostate

5. Ejaculatory duct

16. What is/are secreting of Cowper’s gland?

1. mucous

2. alkaline fluid

3. clotting protein

4. mucous and alkaline fluid

5. alkaline fluid and clotting protein

17. Which gland secrete the greatest constitute of semen volume?

1. Prostate

2. Seminal vesicle

3. Cowper’s glands

4. Paraurethral glands

5. Bulbourethral glands

18. Which gland has the doughnut shape?

1. Prostate

2. Seminal vesicle

3. Cowper’s glands

4. Paraurethral glands

5. Bulbourethral glands

19. How much the volume of semen in one typical ejaculation?

1. 5-10 mL

2. 5-6 mL

3. 2.5-5 mL

4. 2.5-3 mL

5. 1-2 mL

20. Semen coagulates within how minutes?

1. 2 minute

2. 5 minute

3. 10 minute

4. 15 minute

5. 20 minute

Answers

1. D

2. A

3. C

4. E

5. B

6. D

7. D

8. C

9. D

10. A

11. C

12. A

13. E

14. E

15. A

16. D

17. B

18. A

19. C

20. B

by dr.PM

Source: Structure and Function of Accessories ducts and glands.

Soal Adrenal gland, Islet of langerhan, Endokrin

1. As result of the lipid puring tisue preparation,the fasciculata cells appeard vacuolated in commom histological prepaation because of their vacualization ,the cell of the fasciculata also called
a. holocyte
b. vacuocyte
c. spongyocyte
d. pynocyte
e. colimnacytes

2. The layer of adrenal gland that contain lipofuscin pigment granule is
a. zona fasciculata
b. zona reticularis
c. zona glomerusa
e. adrenal medula
e. none

3. The function of chromograin is as ..
a. Binding protein for cathecolamins
b. Binding protein for ATP in adrenal medula
c. Bindin protein for Dopamione
d. BInding pratein for Androgen
e. Binding protein for glucocorticoid

4. What is true abaout islet of langerhan
a. Monohormonal endocrine microorganism
b. Islet are more abindant on several tissue to cause entry of glycogen into cell
c. B cell act on seveal tissuer to cause entry of glycogen into cell
d. The cell type thar has lowest avinity is D cell
e. The cell type that has the highest quantity is B cell

5. A diffuse source of catecolamine
a. paraganglia
b. Postganglia
c. Preganglia
d. Neural Crest
e. ANS

6. The difference betwen adrenal cortex and adenal medula is...
a. The adrenal cortex is red peripheral layer
b. The cell of the medula derived from neural tube
c. DHEA is yhe only sex hormon that is secreted by adrenal medula
d. The cell of adrenal cortex synthesize and secreted steroid hormon upon demand
e. The adrenal medula is a reddish brown peripheral layer

7. ... Stimulates contraction of smooth muscle inthe walls of arterioles
a. renin
b. Angiotensin I
c. Angiotensin II
d. Aldosteron
e. ACE

8. Low blood level of glucocorticoid stimulate neurosecretory cells in the hypothalamus to secrete ...
a. adenocorticoid releasing hormon
b. corticotropin
c. corticotropin stimulating hormon
d. corticotropin realesing hormon
e. adenocorticotropic hormone

9. The hormon produicng cells in the adrenal medula are called ...
a. chromagrain
b. Spongiocyte
c. Pinealocyte
d. Chief cells
e. Chromaffin cell

10. .. produce digestive enzyme
a. Delta cell
b. F cell
c. Acini
d. Tail of pancreas
e. Head of pancreas

11. The secretion of insulin is stimulated by... except
a. ACH
b. Arginin and leucin
c. GIP
d. hGH
e. Increase activity of the sympathetic division

12. 90-95 % of the cortisol in the plasma bind to plasma protein , especialy ...
a. albumin
b. globulin
c. Fibrinogen
d. Serum
e. protrobin

13. Except for that portion of the insulin that combines with the reception is the target cell, the remainder is degarded by the enzme, ... mainly in the liver
a. insulin
b. insulin phospatase
c. insulin esterasse
d. insulin desmotase
e. insulin degradase

14. Glucocorticoid hava the folowing effects, excepts...
a. resistance to stress
b. stimulated lypolisis
c. inhibit WBC
d. Slow wound healing
e. Stimulate immune respone

15. Lipid soluble hormon are
1. Eicosanoid hormon
2. nitric oxide
3. Amine hormon
4. Thyroid hormon

A. 1,2,3
b. 1,3
c. 2,4
d. 4
e. 1,2,3,4

16. The action of water soluble hormon ...
1. Activte adenylate cyclase
2. ATP is converted to cAMP
3. Protein kinase is activated
4. G protein is activated
5. Phospodietilsterase inactive cAMP
6. Water soluble hormone bind to its receptor

a. 6-1-2-3-4-5
b. 6-4-2-1-3-5
c. 6-2-3-1-5-4
d. 6-4-1-2-3-5
e. 6-5-4-3-2-1

17. The receptor of water soluble hormone is located
a. within the cytosol
b. Outer surface of the plasma membaran
c. Inner surface of the plasma membran
d. At nuclear membran
e. Within the nuclear

18. The adrenal gland of the new born is proportionately larger than that of the adult because there is a layer know as
a. Provisional cortex
b. Periphera layer
c. Advance medulla
d. Adrogenic layer
e. Fetal medulla

19. The cell types in islet of langerhan that are located usualy in periphery have the characteristic ...
a. have irregular granul
b. Have function to inhibits release of other isle cell hormon
c. Produce pancreatic polypeptida
d. About 20 % of the total cells in islet of the langerhan
e. Secrete DHEA

20. Secrete granule in adrenal medula contain,excepts..
a. Dopamine & Hydroxylase
c. ATP
c. Chromagrains
d. Enkephalin
e. Cyclic AMP

Latihan Soal MDE Topik : Menstrual Cycle

1. 7 day after ovum and sperm fertilized,the implemented will produce a substance. What is the hormon that saves corpus luteum from degeneration ?
a. LH
b. Progesteron
c. INhibin
d. Oxcytocin
e. hCG

2. The secretion function of corpus luteum can be determined by measuring substance level in plasma and serum. Whai is the substance ?
a. LH
b. Progesteron
c. Inhibin
d. Oxytocin
e. Cytrantoxin

3. What hormon that increase flexibility of the pubic symphipis during childbirth ?
a. Estrogen
b. Oxytocn
c. Relaxin
d. Inhibin
e. Progesteron

4. What hormon is secreted by corpus luteum to maintain the uterine lining during the first semester of pregnancy ?
a. Relaxin
b. Inhibin
c. Progesteron
d. hCG
e. LH

5. The first the female getis called :

6. Which the following statment are correct :
(1) the female reproductive cycle consist of menstrual phase, a preovulatory phase, ovulation and postovulatory phase.
(2) During the menstrual phase small secondary follicle in ovary begin to enlarge while the uterus is sheeding its linning
(3) During the preovulatory phase a dominant follicle continues to grow and begin to rebuild
(4) Ovulation result in the realese of an ovum and the shedding of the uterine lining to nourish and support the realesed ovum
(5) After ovulation, a corpus luteum forms from the ruptured follicle and begine to secrete progesteron and estrogen , which it will continue to do throughout pregnancy if the egg is fertilized
(6) If pregnancy doesn't occur,then the corpus luteum degenerates into a scar callled corpus albican, and the uterine lining s prepared to be shed again

a. 1,2,4,5
b. 2,4,5,6
c. 1,4,5,6
d. 1,3,4,6
e. 1,2,3,6

7. The permanent cessation of menses is called :

8. What hormon that stimulate the initial secretion estrogrn by growing follicle :
a. FSH
b. LH
c. Oxytocin
d. hCG
e. Estradiol

9. What event that are happenend in the uterus during secretory phase :
a. Decresing level estrogen
b. DEgeneration of corpus luteum
c. produce the corpus luteum
d. Vascularization of the superficial endometrium
e. Endometrium is dischargr

10. What hormon is rising during last part of preovulatory phase ?
a. Estrogen
b. Progesteron
c. FSH
d. LH
e. Relaxin

11. After ovulation, a blood clot forms from minor bleeding of the ruptured follicle name :
a. Graafian foicle
b. Secondary folicle
c. Corpus hemorhagicum
d. Corpus luteum
e. Corpus Albican

12. One folicle outgrows the others and become dominant while other degenerate. THis event occur during :
a. Preovulatory phase
b. Ovulatory phase
c. Post ovulatory phase
d. Secretory phase
e. Menstruation phase

13. Which hormon is responsible for the surge of LH at midcycle :
a. FSH
b. LH
c. Progesteron
d. EStrogen
e. Inhibin

14. Which of the following is not the function of the estrogen :
a. maintain secondary sex characteristic
b. Decrease protein anaboism
c. LOwer blood cholesterol level
d. Development of female reproductive organ
e. In moderate levels inhibit realese GnRH and secretion of FSH and L

15. Which hormon that is secreted by granulose cell of growing follicle :
a. estrogen
b. progesteron
c. relaxin
d. inhibin
e. oxcytocin

16. HOw much blood that is discharge during the menstrual phase
a. 25-50 ml
b. 50 - 75 ml
c. 50-100 ml
d. 50- 150 ml
e. 100- 150 ml

Answer :
1. E
2. B
3. C
4. C
5. menarche
6. E
7. Menoupose
8. A
9. D
10. A
11. C
12. A
13. C
14. B
15. D
16. D