58.Blood glucose resulted from hydrolysis of these
compound
(glycogen)
60. Dimmer of cellulose polymer.
A. Lactose
B. Sucrose
C. Cellobiose
D. Gentibiose
E. Maltose
62. It is found in milk
A. Lactose
B. Sucrose
C. Cellubiose
D. Gentibiose
E. Maltose
(A.lactose)
pembahasan: Galactose is derived from intestinal hydrolysis of the disaccharide lactose, the sugar of milk
sumber Harper 26th hal 167
63. What is glycemic index is related to?
A. High protein level
B. High lipid/fat level
C. High fiber level
D. High absorption
E. More solid form à NOT SURE
(D.High absorption)
pembahasan: The increase in blood glucose after a test dose of a carbohydrate compared with that after an equivalent amount of glucose is known as the glycemic index. Fructose and the sugar alcohols are absorbed less rapidly and have a lower glycemic index
sumber: Harper 26th hal.474
64. All monosaccharides will be converted by the liver into
which of the following?
A. Fructose
B. Galactose
C. Glucose
D. Sucrose
E. Maltose
(C.Glucose)
66. Which food contains more lactose?
A. Malt syrup
B. Corn syrup
C. Honey
D. Soybean milk
E. Cow milk
(kayanya E.Cow milk)
70. What is the structure of sphingomyelin?
sumber: harper 26th hal 116
75. Example of lecithin.
A. Prostaglandin
B. Phospholipid
C. Cholesterol
D. Bile acid
E. Sphingomyelin
(E.Sphingomyelin)
76. Which of the following compound is derived from
cholesterol?
A. Prostaglandin
B. Phospholipid
C. Cholesterol
D. Bile acid
E. Sphingomyelin
(D.Bile acid)
pembahasan: cholesterol...is the precursor
of a large number of equally important steroids
that include the bile acids, adrenocortical hormones,
sex hormones, D vitamins, cardiac glycosides, sitosterols
of the plant kingdom, and some alkaloids.
sumber: harper 26th hal.117
77. Determinant of blood osmotic pressure.
A. Myoglobin
B. Globulin
C. Hemoglobin
D. Albumin
E. Water
(B.Globulin)
83. Which of the following is protein conformation disease?
A. Albumin
B. Mad cow disease
C. Hemoglobin
E. Myoglobin
(B.Mad cow disease)
Pembahasan: SEVERAL NEUROLOGIC DISEASES
RESULT FROM ALTERED PROTEIN
CONFORMATION
-Prions
The transmissible spongiform encephalopathies, or prion diseases,They include
Creutzfeldt-Jakob disease in humans, scrapie in sheep, and bovine spongiform encephalopathy (mad cow disease) in cattle.
Sumber: Harper 26th hal 37
84. Which of the following including essential fatty acid?
A. Stearic acid & palmitic acid
B. Oleic acid & linoleic acid
C. Stearic acid & linoleic acid
D. Palmitic acid & linolenic acid
E. Linoleic acid & linolenic acid
(E.Linoleic & linolenic acid)
pembahasan: Linoleic and alfa-linolenic acids are the only fatty acids
known to be essential for the complete nutrition of
many species of animals, including humans, and are
known as the nutritionally essential fatty acids.
sumber: harper 26th hal 190
85. LDL is produced at:
A. Liver
B. Gall bladder
C. Small intestine
D. Colon
E. Pancreas
(A.Liver)
pembahasan: LDL berasal dari VLDL yg dibentuk di liver
sumber: harper 26th hal 206 table 25-1
87. Triglycerides consist of the following
A. 3 phospholipids attached to cholesterol
B. 3 glycerol attached to lipid
C. 3 fatty acids attached to glucose
D. 3 cholesterol attached to glycerol
E. 3 fatty acids attached to glycerol
(E.3 fatty acids attached to glycerol)
90. Chylomicron are produced by the
A. Liver
B. Pancrease
C. Gallbladder
D. Small intestine
E. Colon
(D.Small intestine)
sumber: harper 26th hal 206 table 25-1
soal2 mde fbs 1 no. 58-90
Senin, 14 Januari 2008
SOAL MDE FBS 3
Which explanation is suitable to the microtubule structure?
It’s a polymer of globular actin subunit
Tubulin subunit are arrange in cylindrical tubule
Tubulin subunit consist of 2 alpha monomer
Diameter tubulin subunit is smaller than If
Protofilament is a column built by 2 alpha monomer
Which part of the following cell has tight junction?
Apical
Lateral
Basal
Apikolateral
Basolateral
The most abundant molecule in plasma membrane?
Protein
Lipid
Phospholipid
Cholesterol
The fast moving cell is characterized by pseupodial extension and cytoplasmic streaming, accompanied by fluctuation of certain part of the cell between sol and gel state. What is the certain part?
Plasma membrane
Cytoskeleton
Integral protein
Hydrophilic layer
Hydrophobic layer
Which of the following part cell decadence during the telophase?
Plasma membrane
Chromatin
Nuclear envelope
Centriol
Amoeba movement is involved a certain part of its body. What is the certain movement?
Cytosol
Erythrocyte circulates O2 to all parts of body. Which is suitable to its membrane?
Carbohydrate is attached to its inner surface
Protein is intrinsic factor
Carbohydrate is attached to its outer surface
Membrane isn’t flexible
It is important to studying its cell membrane
Which cytoskeleton is suitable to actin filament?
Desmin
Keratin
Laminin
Spectrin
Vimentin
Common property of all phospholipids molecule in cell membrane?
Hydrophillic
Steroid structure
Water soluble
Amphipathic
Hydrophobic
Which one of these explanations is suitable for modifying protein in golgi?
Protein move from rER to trans golgi
Protein is modified in cis, med, and then trans golgi
Continuous secretion awaiting stimillus for exicytocis
Hormons are secreted continuously from golgi
Fibrous clathrin coated the lysosome membrane
Answer for number 11-14
Electron microscope
Light microscope
Scanning electron microscope
Transmission electron microscope
To be used in school’s laboratory?
Answer:
B. light microscope
To view surfaces of unsection specimens?
Answer:
C. Scanning electron microscope
To view viruses?
Answer:
A. Electron microscope
To view protein and cell’s organelle?
Answer:
A. Electron microscope
Best temperature to preserve enzymes?
Answer:
0o C
Which ion that its concentration can be measured in fluorescence microscope
Answer:
Ca++
Microscope for measuring pH?
Answer:
Flouresence microscope
Microscope that uses video camera and computer to stored its image?
Answer:
Confocal scanning microscope
The statement that’s true for electron microscope?
Answer:
The specimen’s section is 50-100 nm
Principle of flow cytometry?
Answer:
By measuring light they scatter
Disrupting the cell produces a mix of suspend component called?
Answer:
Homogenate
Technique to separate certain organelle from homogenate?
Rate zonal centrifugation
Zone centrifugation
Equilibrium density gradient centrifugation
Density gradient centrifugation
Gradient centrifugation
Answer:
a. Rate zonal centrifugation
Which organism is needs minimal medium for culture?
Answer:
Yeast
Testis biopsy is an example for?
Answer:
??? (Mungkin cell culture kali ya…)
Gram positive bacteria?
Answer:
Bacillus
Why the actual plasma membrane for e.coli is is the inner membrane?
Answer:
Major permeability barrier
If the wavelength is shorter which one will be better?
Answer:
Resolution
Organelle for protein synthesis?
Answer:
Ribosome
Organelle that has many DNA?
Answer:
Nucleus
Organelle for degradation of other organelle or substances?
Answer:
Lysosome
Organelle that transport protein from cis to trans face?
Answer:
Golgi
Polypeptide chain that span the lipid bilayer?
Answer:
???
The true statement for nucleolus?
Answer:
Synthesis rRNA
Which mechanism of plasma membrane involves in transporting molecule to other side of membrane?
Answer:
Flip-flop
Protein that has roles as ion channel?
Answer:
Transporter
Junction that allow small molecules to pass the cells?
Answer:
Gap-junction
The true statement for carbohydrates at plasma membrane?
Answer:
Which one of these following movements is directed by microtubule?
Answer:
Prophase and metaphase are sub stages of mitosis where the chromosomes consist of 2 chromatids. What hold these chromatids during these sub stages?
Answer:
CDk has roles in transition of which phase?
Answer:
Which explaination is the most suitable for cytoskeleton’s structure?
Which solute that has the lowest water concentration?
-
Solution
Glucose
Urea
NaCl
CaCl2
1
20
30
150
10
2
10
100
20
50
3
100
200
10
20
4
30
10
60
100
5
40
5
40
50
1
2
3
4
5
Answer:
???
Which following movement of fibroblast?
Answer:
Rearrangement and polymerization of actin filament
Dominant protein in ECM?
Answer:
Collagen
The first protrusion of fibroblast’s movement?
Answer:
Lamellopodia
Most blood group antigen has?
Answer:
Fucose, galactose, glucose, and N. acethylglucosamine
B antigen has?
Answer:
???
by: AV ^^
SOAL MDE BHP
1. Which statement is TRUE for alternative hypothesis?
Answer: There are some correlations between 2 or more variable
2. Study of deficiency of Vitamin A in Lampung that causes several people become blind. What research?
Answer: Case – Field Research
3. Developmental research?
Answer: Study the pattern and sequence of growth
4. Science as product?
Answer: Limited formulation and statement which are agreed upon by all scientists
5. Science as process?
Answer: A social activity
6. Moral aspect of Epistemology?
Answer: Should be done honesty
7. Nuremberg code?
Answer: As a foundation for standards of medical ethics in many countries
8. Investigator?
Answer: The person responsible for the conduct of the clinical trial
9. Responsibility of investigator?
Answer: All true
10. Issue in writing a research journal?
Answer: ???
11. Roles of epidemiologist?
Answer: All true
12. Pioneer of deductive & inductive thinking?
Answer: Newton
13. Phase 3 of….?
Answer: ???
14. Basic ethic for research that involving human subject?
Answer: ???
15. Research that not uses hypothesis?
Answer: Explorative reseach
16. Meaning of thinking?
Answer: An activity to find the truth of knowledge
17. Formulation of problem?
Answer: Compact and clear
18. Roles of physician?
Answer: Treatment of disease
by: AV ^^
MDE FBS 2
Minggu, 13 Januari 2008
FBS 2
4. What is the form of energy if an athlete starts to
run?
A. chemical energy
B. kinetic energy
C. potential energy
D. radiant energy
E. thermal energy
5. Carbohydrates, lipids and proteins are the main source
of energy in our body. What is the form of energy?
A. Chemical energy
B. Radiant energy
C. Potential energy
D. Kinetic energy
E. Thermal energy
6. Microorganism needs a capsule in order to survive
outside of human body. What kind of system is this?
A. open system
B. closed system
C. isolated system
D. closed system with antibiaritic
E. isolated system with antibiaritic
10. Metabolite or substance that produced from
metabolism activity via lung in form of
A. carbon dioxide
B. disulphur substance
C. urea
D. ethane
12. The purpose of stored carbohydrate and fatty acid on
starvation is
A. To contract muscle
B. Maintain body temperature
C. To produce heat
D. To produce energy
E. To produce work
16. I₂ → monoiodo (Ti) →
A. Oxidation or reduction process of iodine
19. Nuclear energy is used for cancer therapy,i.e gamma
rays. Which of the following determining its activity?
A. Rate of reaction
B. Temperature of reaction
C. Mechanism of reaction
D. Order of reaction
E. Half-life of reaction
20. Biosynthesis of carbohydrate has 5 steps
Acetyl coA HMG coA
HMG coA meralonate
Meralonate isotope IPP and carbon
dioxide
IPP squalence
Squalence carbohydrate
What are these reactions called?
A. redox reaction
B. elementary reaction
C. half life reaction
D. reaction mechanism
E. order of reaction
21. Which of the following factor is influenced by the
activity of enzyme?
A. half life reaction
B. mechanism of reaction
C. order of reaction
D. temperature of reaction
E. rate of reaction
24. Which kinetic reaction is used to determine the
expiry date of the drug?
Elementary reaction
Bimolecular reaction
Slowest reaction
Fast reaction
Fastest reaction
25. What happen to the reaction rate if temperature is
higher than needed for enzyme activity?
A. increase
B. decrease
C. constant
D. stopped
E. equilibrium
27. As an bacteriacide. What is iodine?
A. Oxidant
B. Reductant
C. Oxidation
D. Reduction
E. Antioxidant
28. Which of the following produce free radical in
metabolic reaction?
A. ascorbic acid
B. a-tocaphenol
C. carbon tetrachloride
D. carotenoid
E. flavonoid
32. What are the following factors to predict that redox
reaction can be spontaneous?
A. Delta G and delta S
B. Delta G and delta H
C. Delta H and standard delta H
D. Delta S and standard delta E
E. Delta G and standard delta E
37. In eukaryotic cell, electron transport and oxidative
phosphorylation are localized in mitochondria, which
are also the sites of citric acid cycle and fatty
acid oxidation. Which of the following reaction is
oxidation?
A. Pyruvate to lactate
B. NAD to NADH
C. Fe+++ to Fe++
D. FAD + 2H+ + 2e- FADH₂
E. Ethanol to acetaldehyde
39. The process of electron transport and oxidative
phosphorylation are membrane-associated. In such
system, the conversion of energy is from
A. NADH to ATP
B. NAD to NADH
C. FAD to FADH
D. Cytochrome C to coenzyme Q
E. O₂ to NADH
40. What is Coenzyme Q?
A. Is called cytochrome
B. More –ve NADH
C. More –ve Cytochrome C
D. As Complex I
E. Not containing Fe-S complex
41. Complex I accept electron from NADH, serving as link
between TCA cycle and the ETC. This complex can be
failure by inhibitors
A. hydroquinine
B. cyanide
C. carbon monoxide
D. mercurial
E. All of the above
42. Many details of electron transport and oxidative
phosphorylation have been gained from studying the
effect of particular inhibitors. One of the following
substances is an inhibitor that specially inhibit
Complex IV in ETC
A. Rotenone
B. Azide
C. Carboxin
D. Rotinoic acid
E. Dicumural
43. The matrix surrounded by inner membrane contained
A.
B. Complex II
C. Cytochrome C
D. Complex I
E. [ H+] concentration is greater in matrix than in
intermembrane space
44. The rate of respiration ( Oxygen consumption ) in
mitochondria is tightly regulated, it is generally
limited by the availability of phosphorylation of the
A. ATP
B. NAD
C. ATP
D. ADP
E. FAD
45. How many ATP produced from complete oxidation of
one molecule of glucose?
A. 2 ATP
B. 30 ATP
C. 6 ATP
D. 15 ATP
E. 12 ATP
47. Which is correct about bioenergetic term/phase
below?
A. the 1st law stated that the universe tend forward of increased order
B. the 2nd law stated that the total energy in a system remain constant
C. the enthalpy change of reaction is the heat that can produce when the chemical change
D. ∆G˚ is free energy when it is 37˚C and at PH 7.4
E. the bond is high energy if it can produce more than 3kcal/mole when it is hydrolyzed
49. Mr Ariffin has heart attack. The consequences
displayed by the heart changes are?
A. increase in intracellular oxygen concentration
B. increase in intracellular ATP concentration
C. increase in intracellular H+ concentration
D. decrease in intracellular Na+ concentration
50. Which of the following statement correctly describe
the reduction of one of the electron transfer, NAD+
or FAD?
A. NAD+ accepts two electrons as hydrogen atom to
form NADH2
B. NAD+ accepts two electrons that are each donated
from a separate atom of the substrate
C. NAD+ accepts two electrons as a hydride ion to
form NADHD. FAD release a proton as it accepts two electrons
E. FAD must accept two electrons at a time
53. Dinitrophenol acts as an uncoupler of oxidative
phosphorylation by which of the following mechanism?
A. Activating the H+-ATPase
B. Activating coenzyme Q
C. Blocking proton transport across the inner
mitochondrial membrane
D. Allowing for proton exchange across the inner
mitochondrial membrane
E. Enhance oxygen transport across the inner
mitochondrial membrane
62. Ischemia causes damage to affected tissues.
Reperfusion cause even more tissue damage as free
radical is formed. Some hope for minimizing
reperfusion is in administration of antioxidant. Which
statement is CORRECT?
A. Reactive oxygen species ( free radical ) when
there is addition of 4 electrons at time to oxygen
B. Superoxide anion and hydroxyl anion are 2 forms
of reducing agent
C. Superoxide radical dismatase is naturally occurring
enzyme that protects against damage by
converting oxygen to carbon dioxide
D. Reactive oxygen species damages phospholipids,
protein and nucleic acid
E. Glutathionine protect against hydrogen peroxide
(H₂O₂) by oxidizing oxygen to water
65. Which one contains most starch?
A. candy
B. honey
C. sugar
D. cornflakes
69. Which part of mitochondria electron transfer chains
located?
A. Intermembrane space
B. In the mitochondrial matrix
C. Inner intermembrane of the mitochondria
D. On the outer space of the outer membrane
E. On the inner space of the outer membrane
80. Which is the mobile component in mitochondria
membrane in electron transport chain?
A. Complex I
B. Complex II
C. Complex III
D. Complex IV
E. Cytochrome C
84. Dinitrophenol affect the respiratory chain by?
A. Decrease the permeability of inner mitochondrial
membrane (IMM) to proton
B. Increase electrochemical potential across IMM
C. Short-circuited ATP
D. Inhibit electron flow from NADH to Cyc I
E. Disturb electron movement from Co-Q to complex
II
90. Why diarrhea person become easily dehydrated?
A. GI tract secretes two fold of blood volume
B. GI tract contains electrolyte
C. difficult to drink
D. mostly children
E. susceptible group for GI tract reaction
97. Enzyme inhibitors are molecular agent that interfere
in catalysis, slowing or halting enzymatic reaction.
What is competitive inhibition?
A. Inhibitor that compete with a substrate to bind to
an active site
98. The inhibitor constant [k¡] can predict?
A. The strong inhibition of enzymatic inhibitors
B. Velocity of enzymatic reaction
99. The function of cofactor is
A. as primary catalytic center
B. as electron donor
C. bridging group to bind substrate
D. structure formation of enzyme
E. all of the above
100. Hydrolysis process
A. Couple
B. Anabolic
C. Catabolic
D. Glucogenesis
E. Endergonic
100. The sigmoid phenomena of enzyme is refer to
A. competitive inhibitor
B. uncompetitive inhibitor
C. noncompetitive inhibitor
D. allosteric site
E. all enzyme
101. If Adenine of a double helical DNA consist of 10% of
total base, what would be Cytosine?
A. 10%
B. 20%
C. 30%
D. 40%
E. 50%
102. Enzyme activity is important in medical because
A. to predict prognosis
B. to monitor response of treatment
C. to understand pathogenesis of disease
D. to support diagnostic
E. all the above
103. Which of the following statements is closely
associated with pepsin?
A. active at neutral PH
B. not active at low PH
C. active at high PH
D. an active form of pepsinogen
E. is a group functional enzyme in blood
104. Select the following statements that is closely
associated with zymogen
A. An inactive form of enzyme
B. An active form of enzyme
C. Is not a group of enzyme
D. To catalyze blood clotting
E. Is not found in human
105. If an inhibitor does not alter the Km, the inhibition
is probably
A. competitive inhibitor
B. noncompetitive inhibitor
C. uncompetitive inhibitor
D. not an inhibitor
E. none of the above
108. What do we call an enzyme active affected with a
molecule bind to a certain site?
A. end product enzyme
B. coenzyme enzyme
C. isoenzyme
D. allosteric enzyme
E. feedback enzyme
116. Which of the following can acetyldehyde dehydration
be classified as?
A. oxidoreductase
B. isomerase
C. hydrolases
D. ligase
E. lyases
121. Which of the following given condition in an
enzymatic reaction may appear irreversible?
A. High temperature
B. Under equilibrium condition
C. If the product is thermodynamically far more
stable than the reactant
D. If the product accumulate
E. At high enzyme concentration
122. Function of VB/UB primarily
A. enzyme
B. serotonin precursor
C. coenzyme
D. antagonists
E. antioxidant
123. Who needs vitamin C?
A. Alcoholic
B. Elderly
C. Infant
D. Smoker
E. Adolescent
124. Which of the following increase reaction rate of
non-competitive inhibition?
A. High enzyme concentration
B. High co-enzyme concentration
C. High substrate concentration
D. High temperature
E. High pH
129. Term(s) for catabolic reaction is/are?
A. Glycolysis, lipolysis
B. Protein synthesis, lipolysis
C. Lipogenesis, glycolysis
D. Gluconeogenesis, protein synthesis
E. Glyconeolysis, glycolysis
131. Which of the following enzymes will specially
increased after a myocardial infarction?
A. Glucokinase
B. Creatinine phosphokinase
C. Glycogen phosphorylase
D. Pyruvate dehydrogenase
E. Lactate hydrogenase
132. What are the enzyme that specially increased in
blood when people suffering from liver disease?
A. lipoprotein lipase
B. creatinine phosphokinase
C. aspartate transaminase
D. phosphatase acid
E. lactate hydroxylase
133. Which of the following describes a characteristic
feature of enzymes obeying Michealis-Menten
kinetics?
A. The enzyme velocity is half the maximal rate
when 100% of enzyme molecules contain bound
substrate
B. The enzyme velocity is half the maximal rate
when 50% of enzyme molecules contain bound substrate
C. The enzyme velocity is in its maximal rate when
50% of enzyme molecules contain bound substrate
D. The enzyme velocity is in its maximal rate when all the substrate molecules in a solution are bound by the enzymes
E. The enzyme velocity is independent to the
concentration of enzyme
135. The characteristic of Allosteric inhibitor
137. What is the function of water in our body?
A. substrate on metabolic reaction
B. the source of energy metabolism
C. solvent of trygliceride
D. carries waste product
E. aid in regulation of abnormal
138. First sign of dehydration is thirsty. The other sign
of dehydration is
A. loss in body fat
B. itching
C. weakness
D. cough
E. common cold
140. Why does diarrhea person easily become
dehydrated?
A. GIT juice secreted almost twice fold our blood volume per day
B. GIT juice contain electrolyte
C. diarrhea patient difficult to drink water
D. majority of diarrhea patient are children
E. children is susceptible group for GIT infection
149. Brain needs ___________________ as a
predominate source of energy
A. Glucose
B. Amino acid
C. Fatty acid
D. Glycerol
E. Glutamin
152. Which of the following reflect the catabolic
reaction
A. Glycogenolysis, glycolysis
B. Protein synthesis, glycolysis
C. Glycogenesis, lipolysis
D. Lipogenesis, glycolysis
E. Gluconeogenesis, lipolysis
153. Skeletal muscle will use _____ as a predominant
source of energy
A. glucose
B. fatty acid
C. branch chain amino acid
D. ketone bodies
E. glycerol
158. The pathway from pyruvate to Acetyl CoA
A. Produced lactic acid
B. Is known as gluconeogenesis
C. Is metabolically irreversible
D. Need more energy than its product
E. Is occurring in nucleus
162. During metabolism, the energy released is captured
and transferred by
A. enzymes
B. pyruvate
C. acetyl coA
D. adenosine triphosphate
E. respiratory chain reaction
181. In human body, some molecule pass cellular
membranes by moving through the lipid bilayer or
membrane channel. What is the energy used?
A. chemical energy
B. kinetic energy
C. potential energy
D. radient energy
E. thermal energy
182. In the body, NO is the neurotransmitter. It exist
Less than 10 seconds before change to nitrites and
nitrates. What is the 10 seconds in kinetic term
called?
A. reaction rate
B. rate constant
C. the lifetime
D. the concentration
E. half life
183. Which of the following equations follow Van Hoff’s
osmotic pressure equation?
A. ∏=NmRT
184. A four year old boy had a fever. What compound in
the electron transport chain that decreases the
most in its function?
A. Complex I
B. Complex II
C. Complex III
D. Complex IV
E. Complex V
185. In physical activity,body secrete lots of sweat to
maintain body temperature. Which laws are
involved?
A. Thermodynamic law I
B. Thermodynamic law II
C. Thermodynamic law III
D. Thermodynamic law I and Gibbs free energy
E. Thermodynamic law II and enthalpy
MDE FBS 1
FBS 1
1. The space in the inner membrane of mitochondria is called the matrix. What does it contain?
A. high hydrogen ion concentration
B. low hydrogen ion concentration
C. no ribosome
D. no DNA
E. no protein synthesis
2. The true statement about 3D structure of protein:
A. The 3D structure is determined by sequence of
amino acid
B. The 3D structure has non-covalent bonds
C. The 3D structure only interact with hydrophobic
interaction
D. The 3D structure is not found in human
E. The 3D structure is only important in enzyme
molecule
3. Which statement is associated with three dimensional
structure?
A. primary structure
B. secondary structure
C. tertiary structure
D. primary.secondary,tertiary structure
E. not depending in structure of protein
4. Which of the following statement is true about 3D protein structure if it is heated at high temperature?
A. amino acids will combined with other amino acid
B. protein will function at constant rate
C. will lost it function
D. not effect at all to the protein structure
5. The mitochondria have 2 membranes.The outer
membrane is permeable to small molecules and ions
while the inner membrane is impermeable to most
small molecules and ions,including hydrogen ion.The
inner mitochondria membrane serves the component of
the following
A. All glycolytic enzymes
B. Enzymes for citric acid cycle
C. Fatty acids B-oxidation pathway
D. Amino acid oxidation pathway
E. ATP synthase
6. What is the major element of the cell?
A. C, H, O, N
B. C, H, S, P
C. C, H, S, Na
D. S, P, Ca, Na
E. S, H, Na, C
5’ GAAT GAAT 3’
9. When base sequence of DNA segment likes above,how
many H-bonds these nucleotides segment will have?
A. 8
B. 16
C. 18
D. 20
E. 24
12. Under physiological condition, secretion of protein maybe through which of the following?
A. Vesicle
B. Across lipid bilayer
C. Using protein membrane as transporter
D. To build complex with Ca+++
E. Should bind enzyme molecules
13. What is NOT the basic field in medical science?
A. Biology
B. Chemistry
C. Biochemistry
D. Nutrition
E. Statistics
15. What kind of glucose in human body cell?
A. D-Glucose
B. L-Glucose
C. Both of them
D. None
E. Bind with ATP
17. Protein can be denatured by which of the following?
A. Concentrated urea solution
B. Oxygen
C. Strong acid
D. Concentrated ethanol solution
E. Heat
19. Which is isotonic solution?
A. Glucose 0.9%
B. CaCl2 0.9%
C. KCl 0.9%
D. NaCl 0.9%
20. The body needs chloride, sodium, potassium, etc. What
are these solution are called?
A. Acid
B. Base
C. Electrolyte
D. Salt
E. Reactant
21. Before decide the appropriate class of drug, what is the
term used in experiment by researchers?
A. Concentration
B. Molar
C. Molality
D. Normality
E. Percent
22. What is the function of bile acid in lipid digestion?
A. Electrolyte
B. Emulsifier
C. Dispersing Agent
D. Solvent
E. Solute
23. Albumin function is maintain osmotic pressure. What is
the colligative properties that can stop osmotic
pressure?
A. Boiling point elevation
B. Freezing point depression
C. Osmotic pressure
D. Vapour depression
E. Vapour depression and osmotic pressure
24. Which one is not colloid?
A. Oil in water
B. Benzoic acid in water
C. Smoke
D. Milk
E. Butter
26. Colloid state for gelatin dessert
A. Both are solid
B. Both are liquid
C. Dispersing medium liquid, dispersing phase solid
D. Dispersing medium solid, dispersing phase liquid
E. Both are gas
27. Forest burning causes air pollution. What type is fog?
A. Aerosol
B. Foam
C. Emulsion
D. Solid foam
E. Solution
28. What is the form of shaving cream?
A. Aerosol
B. Foam
C. Solid foam
D. Solution
E. Emulsion
30. Free radical can oxidized unsaturated fatty acid. What type of bond & type of reaction occur?
A. Single bond & redox reaction
B. Double bond & redox reaction
C. Triple bond & redox reaction
D. Sigma bond & redox reaction
E. Pi bond & redox reaction
32. Which of the organic compound produce substance in
transform with additional reaction?
A. Alcohol
B. Alkene
C. Alkyne
D. Ethers
E. Aliphatic
34. Which of the ketone bodies that has/have volatile
properties?
A. Acetoacetic acid and hydroxybutyric acid
B. Acetoacetic acid and acetone
C. Hydroxybutyric acid acetone
D. Acetone
E. Hydroxybutyric acid
36. Which of the following bond can NOT make conformation?
A. Sigma bond
B. Pi bond
C. Single bond
D. Double bond
E. Triple bond
37. Which of this organic compound can interact with central
Nervous System?
A. benzene
B. carboxylic acid
C. cystein
D. diethyl ether
E. paraffin
39. Bovine insulin composed of two polypeptide chains. What
kind of bond joined these two polypeptides?
A. Charge bond
B. Covalent bond
C. Disulfide bond
D. Hydrogen bond
E. Peptide bond
40. Aldehyde and ketone are important groups for identifiying
monosaccharides.What are the type of reaction that
occur?
A. Group transfer reaction
B. Redox reaction
C. Rearrangement reaction
D. Hydrolysis
E. Elimination
41. Which of the following antibiotic has many member lactones
ring in its structure?
A. Cannamycine
B. Chloramphenicol
C. Erythromycine
D. Penicilline
E. Tetracycline
42. Which of the following antibiotic has chloride in its
structure?
A. Bacitracin
B. Chloramphenicol
C. Penicillin
D. Polymyxin
E. Streptomycin
43. Structure found in animal glycoprotein
44. Found in eye’s diabetic person
45. Uronic acid
47. To decreased cerebral pressure
48. Detoxifying agent
49. Structure of Mannitol
50. Cell wall of gram-positive bacteria consisting of multiple
layers of these compound
A. Dextrans
B. Peptidoglycan
C. Glycosaminoglycan
D. Glycoprotein
E. Glycogen
51. Chondroitin Sulphate is an example of this compound.
A. Dextran
B. Peptidoglycan
C. Glycosaminoglycan
D. Glycoprotein
E. Glycogen
52. This compound is abundant in muscle tissues;where it is
More immediately available for energy release
A. Dextran
B. Peptidoglycan
C. Glycosaminoglycan
D. Glycoprotein
E. Glycogen
54. The compound that produce in the liver and acts as
stored energy organ in an animal
A. Dextrans
B. Peptidoglycan
C. Glycosaminoglycan
D. Glycoprotein
E. Glycogen
56. A single layer of gram-negative bacteria is
58. Blood glucose resulted from hydrolysis of these
compound
60. Dimmer of cellulose polymer.
A. Lactose
B. Sucrose
C. Cellobiose
D. Gentibiose
E. Maltose
62. It is found in milk
A. Lactose
B. Sucrose
C. Cellubiose
D. Gentibiose
E. Maltose
63. What is glycemic index is related to?
A. High protein level
B. High lipid/fat level
C. High fiber level
D. High absorption
E. More solid form à NOT SURE
64. All monosaccharides will be converted by the liver into
which of the following?
A. Fructose
B. Galactose
C. Glucose
D. Sucrose
E. Maltose
66. Which food contains more lactose?
A. Malt syrup
B. Corn syrup
C. Honey
D. Soybean milk
E. Cow milk
70. What is the structure of sphingomyelin?
Ans: D
75. Example of lecithin.
A. Prostaglandin
B. Phospholipid
C. Cholesterol
D. Bile acid
E. Sphingomyelin
76. Which of the following compound is derived from
cholesterol?
A. Prostaglandin
B. Phospholipid
C. Cholesterol
D. Bile acid
E. Sphingomyelin
77. Determinant of blood osmotic pressure.
A. Myoglobin
B. Globulin
C. Hemoglobin
D. Albumin
E. Water
83. Which of the following is protein conformation disease?
A. Albumin
B. Mad cow disease
C. Hemoglobin
E. Myoglobin
84. Which of the following including essential fatty acid?
A. Stearic acid & palmitic acid
B. Oleic acid & linoleic acid
C. Stearic acid & linoleic acid
D. Palmitic acid & linolenic acid
E. Linoleic acid & linolenic acid
85. LDL is produced at:
A. Liver
B. Gall bladder
C. Small intestine
D. Colon
E. Pancreas
87. Triglycerides consist of the following
A. 3 phospholipids attached to cholesterol
B. 3 glycerol attached to lipid
C. 3 fatty acids attached to glucose
D. 3 cholesterol attached to glycerol
E. 3 fatty acids attached to glycerol
90. Chylomicron are produced by the
A. Liver
B. Pancrease
C. Gallbladder
D. Small intestine
E. Colon
91. What is the vehicle transport for lipid in blood?
A. Micelle
B. Lipoprotein
C. Blood vessel
D. Monotriglycerides
E. Polytriglyceride
93. This structure shows Cytosine
94. Phosphodiester linkages
95. This base Nitrogen can be found in DNA or RNA
96. Glycosidic linkage
97. The structure shows Cytidilic acid
98. Given the bases segment of 1 strand DNA – 5’GAATGAAT
A. 5’AGGCAGGC
B. 5’TGGCTGGC
C. 3’AGGCAGGC
D. 3’CTTACTTA
E. 3’GAATGAAT
100. What is the most important biological function of
nucleotide?
A. Precursor for synthesis of nucleic acid
B. Storage energy
C. Structural function of membrane
D. Transmission of nerve impulse
E. Immumne protection
102. Which one is the medical application of nucleobases,
nucleosides and nucleotides?
A. They act as bacterial agent
B. They act as therapy of fever
C. They act as hormone substitute
D. They act as emulsifying agent
E. They act as cancer chemotherapy
103. Which part of amino acid chemical structure differentiates one
from another?
A. double bonds
B. side groups
C. acid groups
D. carboxyl group
E. amino group
104. What is the meaning of essential amino acid?
A.The body that can synthesize them for itself
B.The body that can synthesize it from fat
C.The body that can synthesize it from carbohydrate
D.The body that can’t make in sufficient quantity
E.The body can’t synthesize it from vitamins
105. Sometimes non-essential amino acid becomes essential
amino acid under special condition, which is including
conditionally essential amino acid?
A. Valine
B. Methionine
C. Glutamine
D. Leucine
E. Isoleucine
106. What is the major event of protein digestion in stomach?
A.
B. Mechanical process which cutting larger molecules into smaller molecules
C. Catalyze by several enzymes
D. Emulsifiers
E.
107. What is the fate of amino acid after enter cell?
A. Oxidise to energy and store as protein
B. Oxidise to energy and change to protein
C. Change to lipid
D. Store as protein
E. Build to enzyme
108. What function of protein should be avoided during starvation?
A. Protein as a building material
B. Protein as hormone
C. Protein as regulator of fluid balance
D. Protein as acid-base balance
E. Protein as a source of energy
109. What is the meaning of protein turnover?
A. The amount of protein on food before eating
B. The amount of protein absorb from diet
C. The amount of protein used for energy
D. The amount of protein found in albumin
E. The amount of protein synthesized and degraded
113. Which of the foodstuff has a highest protein quantity?
A. rice, banana, soy
B. rice, apple, milk
C. soy, apple, milk
D. soy, egg, milk
E. egg, asparagus, milk
114. What is a pair of food that can provide COMPLETE protein?
A. French fries and fried chicken
B. Rice porridge and chicken
C. Chicken and nasi gudeg
D. Sticky black rice and green bean
E. Porridge rice and asparagus soup
115. Which of these food contain no protein?
A. rice
B. milk
C. oil
D. soy bean
E. tofu
116. What is the effect if person take a lot of protein?
A. healthy
B. dehydration
C. obesity
D. edema
E. heart disease
117. Which of these food contain the highest amount of nucleic
acid?
A. chicken skin
B. corn
C.
D. red meat
E. egg
118. What are vitamins?
A. Inorganic molecules
B. Need in large amount
C. Required in most catabolism reaction
D. Are soluble in either water or fat
E. Performed best when linked in big molecules
124. Function of vitamin C?
A. Intrinsic factor
B. Antagonist
C. Coenzyme
D. Antioxidant
E. Energizer
125. What is good source of vitamin A?
A. Whole-wheat bread, green peas, tuna
B. White bread, apples, noodles
C. Oats, pintot beans
D. Liver, apricot, turnip
E. Corn, grapefruit juice, sunflower
127. What is the body precursor to make vitamin D?
A. Cholesterol
B. Bilirubine
C. B-Carotene
D. Tocophenol
E. Creatinine phosphate
128. What is vitamin
A. inorganic molecules
B. need in large amount
C. required in most catabolism reaction
D. are soluble in either water or fat
E. perform best when link in big molecule
129. What is the characteristic of fat soluble vitamin?
A. It is easily excreted
B. It is not stored in muscle tissue
C. It seldom cause toxicity
D. It is secreted from intestine by lipoprotein
E. It is secreted through urine
132. What is the role of Vitamin C?
A. Physiological nerve function
B. Required for fat formation
C. Required for collagen production
D. Coenzyme in lipid and carbohydrate metabolism
E. Promote heme-iron production
133. Source of vitamin B:
A. Red meat, egg
B. Banana, pineapple
C. Fresh fish, milk
D. Pineapple, red meat
E. Milk, leafy vegetables
134. What is the function of niacin?
A. A coenzyme in…..
B. A coenzyme of NAD and NADP
C. A coenzyme of …..
D. Synthesis of myelin
E. Immune function
135. What is true about vitamin B12?
A. Unstable when heating
B. RDA is 300mg
C. source from tempe
D. deficiency disturb respiration
Case 2
Jumat, 28 Desember 2007
Cell Cycle & Cell Division
Interfase
G1 – S – G2
Fase Mitotik : Mitosis, Meiosis
Profase – Metafase – Anafase - Telofase
Pasien:
Laki-laki, 3 yrs
Keluhan:
Ada lesi (bintil) di paha kiri
Semakin merah, lunak, dan bernanah
Hasil permeriksaan:
— Pembengkakan lymph node
— WBC naik
— Ada infeksi staphylococcus (+)
Diagnosa:
Abscess
Perawatan:
— Abscess di kompres
— Pemberian antibiotik selama 5 hr
Lab Activity:
Mengamati proses pembelahan sel pada mikroskop cahaya
Prosesnya:
— Sel / jaringan dibiakkan di medium tertentu selama kurang lebih 36 jam (kalo ga salah)
(*pokoknya sampai masuk ke fase mitotik)
— Sel / jaringan tersebut diberi zat kimia tertentu sehingga sel yang mengalami mitosis terhenti.
— Sel diamati dengan mikroskop cahaya
Mekanisme
Infeksi staphylococus (+)
Menghasilkan zat kimia (hyaluronidase)
Jaringan di sekitar infeksi rusak
Proteksi tubuh
Vasodilatasi
Kebutuhan WBC (neutrofil) naik
Pembentukan WBC naik
Neutrofil migrasi (diapedesis) ke sumber infeksi
Pembesaran lymh node
Ekstravasasi WBC meningkat
Nanah
Abscess
Kasus abscess di atas berhubungan dengan basic science:
Cell Adhesion
Diapedesis netrofil melalui sel epitel pembuluh darah (di daerah yg ikatan antar selnya terputus)
Cell motility
Diapedesis netrofil dari pembuluh darah ke ECM
Extra Cellular Matix (ECM)
ECM merupakan area yang terinfeksi (Hyaluronic acid terurai oleh Hyaluronidase)
Cell Cycle & Cell Division
Pembentukan WBC yang meningkat dihasilkan dari perkembangan dan pembelahan sel.
soal mde fbs 1
Kamis, 27 Desember 2007
5. inner matrix mitochondria...
a. as.amino oxidasi pathway
b. oxidasi fatty acid pathway
c. enzyme aiklus krebs
d. enzim glikolisis
e. ATP synthase
6. Elemen dasar..
Answer : C, H, O, N
10. Substance that produce from metabolic activity out from lung is in the form of...
a. CO2
b. urea
c. sulfur
d. albumin
e. metana
11. Kandungan matrix mitokondria?
12. Under physiological condition, the secretion of protein maybe through...
18. amino acids containing imydazole...
a. glysin
b. methionine
c. valine
d. arginine
e. histidine
answer : e. histidine
21. Sebelum ngasih obat, resercher used term in experiment called...
a. concentration
b. molaritas
c. molality
d. normality
e. percent
answer : a. concentration
22. Function of bile salts in digestin of fats....
a. emulsifier
b. solute
c. solvent
d. electrolyte
answer : a. Emulsifier
32. which the organic compound that can produce a substance in the following of addition reaction?
a. alkohol
b. alkene
c. alkine
d.
e.
33. Reaksi apa yang terjadi pada ATP untuk menghasilkan energi?
38. Vitamin is needed to stop bleeding?
Answer : vit.K
40. aldehyde and ketone are important groups for identifying monosacharide. What reaction that occurs?
a. group-transfer
b. redox
c. rearrangement
d. hydrolisis
e. elimination
answer : b.redox
44. Struktur sorbitol?
45. Tentang uronic acid
48. Tantang detoxifying agent
Dr 50-54
a. dextran
b. glycoprotein
c. glycogen
d. glykosaminoglikan
e. peptidoglikan
50. Gram (+) bacterial cell walls contain multilayer of this compound...
Answer : peptidoglycan
51. Condroitin sulfat merupakan contoh dari compound apa?
52. This compound abundance in muscle tissue, where it is use for energy realese?
54. This compound stores in the liver as the major energy storage?
56. gram negative bacteries contaon single layer of...
Answer : proteoglycan
57. for exa,ple, the mucins found extensively in salivary secretion, contain many short o-linked
58. Blood glucose is resulted from hydrolisis of this compound...
61. it is a non reducing sugar
a. lactose
b. sucrose
c. cellubiose
d. gentibiose
e. maltose
62. found in milk..
Answer : lactose
66. Lactose terkandung di..
Answer : susu sapi (cow milk)
67. Struktur dari fatty acid?
68. Struktur dari sphingosine?
69. Struktur dari choline?
70. Struktur dari sphingomyelin?
71. Struktur dari phosphic acid?
74. Triester with glycerol 3-phosfat?
75. Lechitin termasuk apa?
76. Which of the following compounds are derivative from cholesterol
a. prostaglandin
b. phospholipid
c. cholesterol
d. bile acid
e. sphingomyelin
83. . . . is the protein conformation disease
a. albumin
b. mad cow disease
c. Hb
d. collagen
e. myoglobin
88. True about saturated fatty acid?
a. all have 8 long carbon
b. all have 18 long carbon
c. at least one double bond
d. fully hydrogen
e.
89. What is the different between cis and trans fatty acid?
a. number of double bond
b.
c.
d. configuration between double bond
e. number of carbon
93. struktur dari cytocyne
95. Struktur basa yang ditemukan dalam DNA & RNA (soalnya dlm bentuk gambar)
98. Given the bases sequent of a segment of one strand DNA
Answer : 5’GAATGAAT
100. What is the most important bio function nucleotids?
106. What is the major event of protein digestion in the stomach?
a. the partial breakdown of protein
b. mechanical digestion
c. digestion by several enzymes
d. emulsifies protein & release peptides
e. condenses protein
111. In what condition nitrogen balance positive occurs?
115. makanan yang tidak mengandung protein..
a. bread
b. milk
c. oil
d.
e.
116. kelebihan protein akan menyebabkan?
a. healthy
b. dehidrasi
c. edema
d. obesitas
e.
119. The factor that effect vitamin bio availability?
a. the amount of food
b. body weight & body heigh
c. other food consumption at the same time
d. food composiyion
e. method of food storage
120. How to minimize vitamin losses for the food?
a. rinses fruit and vegetables ...
b.
c. put fruite & vegetables in warm water
d.
e. cook fruit and vegetable in high temperature
123. Which of following condihons need of vitamin c is highest?
a. alcoholic
b. the eldery
c. the infant
d. smokers
e. adolescent
129. Karakteristic fat.soluble vitamin?
a. mudah diekskresikan
b. diekskresikan lewat urine
c. dr usus lalu liver ditransport oleh lipoprotein
d. tidak didimpan di jaringan tubuh
e. jarang mencapai level toxic
170. LDL is produce in the following organs?
a. small intestine
b. ball badler
c. liver
d. pankreas
e. kolon