Soal COMPRE part 2

Comprehensive Test Part 2

1. Jika terjadi deficiency Carbonic Anhidrase apa yang terjadi?

a. Eksresi Na⁺

b. Eksresi K⁺

c. Inhibit HCO^3-

d. Peningkatan plasma pH

e. Eksresi H⁺

2. Transport of K+ in what tubule?

a. proximal convoluted

b. descending limb

c. proximal straight

d. collecting duct

e. thick ascending limb

3.

4. The primary means of regulating body water gain is adjusting…

a. the volume of water intake

b. rate of cellular respiration

c. the formation of metabolic water

d. the volume of metabolic water

e. the metabolic use of water

5. PCO2 naik?

Answer : respiratory acidosis

6.

7. Micturition reflex initiated by…

Answer : stretch receptor in urethra

8.

9. Which of the following statement is correctly about the fluid in the juxtamedullary nephron?

a. It enters the loop of Henle hypertonic to plasma

b. It enters the loop of Henle hypertonic to plasma

c. It enters the loop of Henle isotonic to plasma

d. It leaves the loop of Henle isotonic to plasma

e. It leaves the loop of Henle hypertonic to plasma

10.

11.

12.

13.

14.

15. Yang dipunyai Gram (+)….techoic acid

16.

17.

18.

19. The steps leading to the synthesis of peptidoglycan occur in the cytoplasm, on the cytoplasmic membrane, and extracellularly. Which antibiotic inhibits the extracellular step in peptigodglycan biosynthesis?

a. Bacitracin

b. Cycloserine

c. Penicillin

d. Rifampin

e. Streptomycin

20.

21.

22.

23. Which of the following genital flora microorganism is present in a significant decrease in bacterial vaginosis?

a. Candida albicans

b. Corynebacteria species

c. Lactobacillus species

d. Prevotella species

e. Staphylococcus epidermis

24.

25. S. Pnemoniae merupakan flora normal di…

a. hidung

b. nasopharynx

c. esophagus

d. lambung

e. colon

26.

27. Man à abdominal cramp & diarrhea

Mac-konkey à inoculated & grow gram negative rod

Kriegler à isolate shigella & salmonella

Untuk membedakan kedua pathogen…?

a. fermentasi glukosa

b. tidak bisa fermentasi sukrosa & laktosa

c. motility in medium

d. produce gas in medium

e. produce urease

28.

29. Gram (-) bacillus, oxidase (+)

a. E. coli

b. Proteus

30. Virus RNA dependenet RNA polymerase characteristic?

a. semua virus RNA punya

b. tidak perlu bantuan dari host cell untuk polymerasenya

c. hanya negative-stranded yang punya

d. ada pada RNA corenya

31.

32. A synthetic that inhibits influenza virus by blocking viral uncoating for treatment?

a. acyclovir

b. amantidine

c. lamivudine

d. ribavidin

33.

34.

35.

36.

37. 2 year old suffering diarrhea, rotavirus was suspected. Cara yang tepat untuk diagnosis virus itu?

a. detection virus by enzyme linked immunoassay (ELISA)

b. fluorescent staining stool

c. light microscopy…

d. stool culture to find shigella, campylobacter, salmonella

e. viral culture

38.

39. menderita penyakit ginjal selama 5 tahun, kemudian ditreatment mengakibatkan lymph… disorder. Virus apa yang menyebabkannya?

Answer : Epstein Barr Virus (?)

40. Correct about rhinovirus?

a. amantidine protect against infection

b. there are three antigen type

c. most common for common cold

d. can’t survive in environmental condition

41. Intestinal nematode that passed through lung first before become adult in intestine

a. Trichostrongilloides culibro

b. Trichiuris trichiura

c. Trichinella spiralis

d. Enterobius vermicularis

e. A. cantonensis

42.

43. Habitat Ascaris lumbricoides?

a. duodenum

b. colon

c. jejunum

d. rectosigmoid

e. proximal ileum

44.

45. Mode of transmission of Amubiasis?

a. Flies as biological vector

b. Food contaminated vegetative stage

c. Insect bite

d. Congenital

e. Flies as mechanical vector

46.

47. Causing scrotal swelling?

a. Wuchereria bancrofti

b. Brugia malayi

c. Brugia timori

48.

49.

50. Lympathic filariasis à transmission methodnya?

a. TOT

b. Cyclico developmental

c. Propagative

d. Cyclico propagative

e. hereditary

51.

52.

53.

54.

55.

56.

57.

58. Ada kemungkinan anak menderita apa lagi?

a. Trichuriasis

b. Ambiasis

c. Cutaneus larva migrant

d. Ascariasis

e. Oxyuriasis

59. s

60. s

61. Based on her medical record, Mrs.R has been diagnosed as having hepatic carcinoma. All of the following parasite in its life cycle may pass through the liver, but not all of them may live in the liver. Which of the following parasite can live surrounds the blood vessels in the intestinal tract and the liver?

a. Necator americanus

b. Schistosoma japonicum

c. Ascaris lumbricoides

d. Plasmodium falciparum

e. Fasciola hepatica

62.

63. Amoeba which can cause diarrhea..?

a. Plasmodium falciparum

b. Balantidium coli

c. Entamoeba hystolitica

d. Giardia lamblia

64.

65.

66. Parasite infection menyebabkan abdominal pain. Di bawah ini yang merupakan abdominal pain resemble duodenal ulcer adalah…

a. Cochin Cina diarrhea

b. Lambliasis

c. Intestinal amoeba

d. Ucinariasis

e. Ascariasis

67.

68. A 50 years old man suffers from acute abdominal pain. The pain is constant and intense to his upper back. Lab findings show elevated plasma level of amylase & lipase. Which is the right as a group abnormality cytoskeletal?

a. decrease phospholipids of mitochondria

b. increase uptake of Ca2+ in mitochondria

c. degradation & activation of phospolipase

d. unstratified free fatty acid

e. activation of protease

69.

70. Reversible injury?

Answer clumping of chromatin

71.

72.

73. Extravasasi pada leukocyte di lumen

a. migration-rolling-adhesion

b. margination-rolling-adhesion

c. margination-rolling-adhesion-migration

d. rolling-adhesion-migration

74.

75.

50 years old man came to visit clinical lab RSHS for regular checked of his DM. Lab staff took 2 ml blood from him.

76. To what subdivision that labstaff have to send the blood?

a. Clinical hematology

b. Clinical chemistry

c. Clinical immunology

d. Clinical microbiology

e. Clinical parasitology

77.

78.

79.

80.

81.

82.

83. The congenital disorder in bilirubin metabolism that caused by reduce activity of bilirubin- UDP-glucoronidtransferase?

a. Gilbert’s syndrome

b. Crigler-Najjar syndrome

c. Dubin Johnson syndrome

d. Rotor syndrome

e. Hemolytic disease of newborn

84.

85.

86. Increase urea in urine due to…?

87. mucosa-shorted vili, lymphocyte in lamina propria

a. Rotavirus

b. Entamoeba hystolitica

88.

89. If she suffers rice water diarrhea that contain flecks of mucous, and the microscopic feature shows that the microba never invade epithelium but remain within lumen. What is the etiologic of the disease?

a. Clostridium botrium

b. S. flexneri

c. V. cholerae

d. Rotavirus

e. ETEC

90.

91.

92. If hematocrit centrifugation needs 1000 rpm, what will happen if we use 800 rpm?

a. Blood will lysis

b. Hematocrite abnormal

c. Hematocrite normal

d. Hematocrite is lower than normal

e. Hematocrite is higher than normal

93.

94. Neutrophil PMN = Norman, Basophil = normal, Eosinophil = increase. What is condition of this patient?

a. Neutrophilia

b. Eosinophilia

c. Basophilia

d. Leukocytosis

e. Lymphocytosis

95. A 20 years old lady come to primary health center with a chief complaint of dizziness. From the physical examination and laboratory result, the doctor diagnosed this lady as anemia. What further laboratory test to classify her anemia?

a. RBC index

b. Hb

c. RBC count

d. Hematocrit

e. BSR

96.

97. Laboratory technician performed Hb measurement with hemiglobincynadin method. She needs 20ul of blood. What will happen if she took 25 ul blood?

a. blood lysis

b. blood to dilute

c. Hb level will be normal

d. Hb increase

e. Hb decrease

98. Which of the following is lower risk of thrombosis in hypercoagulability status?

a. prolonged bed rest

b. MI

c. Arterial fibrillation

d. Congestive Heart failure

e. Nephrotic syndrome

99.

100. Bilirubin causes prolong jaundice and bound to albumin…

a. α-albumin

b. β-albumin

c. γ-albumin

d. δ-albumin

e. θ-albumin

101.

102. What process occurs to creatinine in the tubule

a. secretion

b. excretion

c. reabsorption

d. diffusion

e. filtration

103.

104. What process occurs to urea in the tubule?

a. secretion

b. excretion

c. reabsorption

d. diffusion

e. filtration

105. Which from this renal function test is affected by muscle atrophy?

a. creatinine level

b. Fractional excretion

c. BUN

d. Cystatine C

e. Fractional reabsorption

106. Apa yang meningkat jika anion gap meningkat?

a. lactate

b. ketone

c. creatinine

d. glucose

e. urea

107.

108.

109. What is the most abundant cation in extracellular fluid?

a. sodium

b. potassium

c. calcium

d. magnesium

e. ferrum

110. pH=7,3, pCO₂=normal, HCO^3-=increase

a. metabolic acidosis

b. metabolic alkalosis

c. uncompensation acidosis

d. respiratory alkalosis

e. respiratory acidosis

111. Bronchial asthma with respiratory acidosis are the result of which mechanism disturbance?

a. Inhalation of CO₂

b. Exhalation of CO₂

c. Excretion of HCO^3-

d. Secretion of H⁺

e. Secretion of NH₄⁺

112.

113.

114. Rhabdomyosarcoma pada lower one third leg. Definisi rhabdomyosarcoma?

a. Malignant of skeletal muscle

b. Malignant of smooth muscle

c. Benign of skeletal muscle

d. Benign of smooth muscle

e. Malignant of melanocyte

115. Characeristic benign tumor

a. slow grow, infiltrative, metastasis

b. slow grow, small, doesn’t metastasis

c. fast grow, small, metastasis

d. fast grow, infiltrative, doesn’t metastasis

e. fast grow, enormous, metastasis

116. Ovarian tumor pada female 27 years old dengan pembesaran 9 cm, teeth and hair?

a. choristoma

b. hamartoma

c. teratoma

117. A 5 years old boy has a lung mass contain normal cartilage & disorganized lung tissue?

a. Chondroma

b. Hamartoma

118. A 40 years old female has just received her pap smear test. In the microscopic description the pathologic describe her smear contain atypical cells that shows anaplasia. Which of the following statement is characteristic of anaplasia?

a. cell & nucleus pleomorphic in size & shape

b. nucleus content more DNA & hyperchromatic

c. Prominent cytoplasm

d. A + B

e. A + B + C

119. 50 years female had an ulcerative tumor in his face. He was told that the tumor was malignant but rarely metastatic. Which of the following cancer is the most likely describing that conditions?

a. small cell carcinoma

b. squamous cell carcinoma

c. basal cell carcinoma

d. large cell carcinoma

e. rhabdomyosarcoma

120. A 55 years old female had breast tumor and large axilla lymph node. The most common way to metastasize for this tumor is via?

a. hematogenous

b. bone

c. perineural fluid

d. lymphatic

e. serous sac

121. A 65 years old male had a tumor called colorectal carcinoma through the GIT. The most common way for the carcinoma to metastasize is via?

a. lymphatic

b. blood vessel

c. perineal cavity

d. bone

e. serous sac

122.

123. Paracancerous lesions…

a. Bowen’s disease

b. Celiac disease

c. Teratoma

d. Fibroadenoma

e. Lipoma

124. Virus yang dapat menyebabkan kanker..?

a. EBV, HepB, HepA

b. HPV, HIV, HepB

c. HTLV1, HepA,…

d. HepB, HepD, HPV

e. HTLV1, HepA, HPV

125. Molecule that plays a role in regression tumor?

a. IL-2

b. CK-7

c. CA-125

d. PSA

e. HCG

126.

127. Step in carcinogenesis?

Answer : initiation à promotion à progression à methastasize

128.

129.

130. s

131. Excess physiological stress or pathogenic stimuli is resulted in…

a. accumulation

b. cell growth

c. reversible injury

d. adaptation

e. cell homeostatis

132. Penyebab pneumonia

a. reduction oxygen carrying-blood capacity

b. infeksi viral-bakteri

c. reduksi oksigen…

d. poisoning CO

133. Mr. Beckham seorang atlet sepakbola yang baik. Dia selalu berlatih.

a. hipertopi, hyperplasia

b. hipertropi, atropi

c. hyperplasia, anaplasia

d. hyperplasia, metaplasia

e. hipertropi, adaptation

134.

135. Decrease of cell size, called…

a. hypotrophy

b. necrosis

c. atrophy

d. hypertrophy

136. Pecahnya nucleus menjadi fragmen-fragmen disebut…

a. karyolisis

b. karyohexis

c. pyknosis

137. Yang mengakibatkan cell injury?

138.

139.

140.

141. Meningkatnya kadar protein di jaringan otak karena…

a. meningkatnya permeabilitas BBB

b. menurunnya resorption arachnoid vili

c. mechanical obstruction

142. In CSF, enzyme yang ada karena seizure..?

a. amilase

b. creatinin kinase

c. ALP

d. Adeno diaminine

e. LD

143.

144. Which of the following anticoagulant used for lactate and enzyme test in synovial fluid test

a. Li-Heparin

b. Na-Heparin

c. K2-EDTA

d. Citrate

e. Oksalat

145.

146. Ascites in hepatic cirrhosis is due to..?

a. decrease plasma oncotic pressure

147. Blood glucose level determination mostly performed with spectophotometry. What important equation we applied in this method?

a. Timbal

b. Rayligh

c. Beer-Lambert

d. Raman

e. Planck

148. Spectrophotometer is a useful laboratory diagnosis. In this method, we use cuvette. Equipment placed after this borosilicate glass is...

a. exciter lamp

b. entrance slit

c. monochromator

d. exit slit

e. photodetector

149. In spectrophotometer we use electromagnetic radiation. Component of spectrophotometer that will provide radiation?

a. exciter lamp

b. entrance slit

c. monochromator

d. exit slit

e. photodetector

150. Spectrophotometer is a useful laboratory diagnosis. In this method, we use interfering filter. Which part of spectrophotometer use this filter?

a. exciter lamp

b. entrance slit

c. monochromator

d. exit slit

e. photodetector

151.

152. Administration of salbutamol which is the most convenience for acute asthma attack?

a. subcutaneous

b. intramuscular

c. intracutaneus

d. by nebulizer

e. intranasal

153.

154.

155. Effect adrenalin + local anesthetics:

a. increase DOA

b. increase OOA

c. increase MOA

d. decrease OOA

e. decrease DOA

156. Which of the following is the process studied in pharmacodynamic?

a. clearance

b. interaction between drug-receptor

c. first-pass metablolism

d. bioavailability

e. enzyme activity

157. Salbutamol à efek ke β2 di bladder wall?

a. constriction of muscle

b. relaxation

c. no change

d. reduce urine volume

158. Which of the following is the caused of prolong used by acetaminophen?

a. emboli

b. prolong beeding time

c. platelet aggregation

d. congestive heart failure

e. hepatic disorder

159.

160. Aspirin contraindication gastritis. Why..?

a. increase pepsine

b. induction of TX

c. decrease HCl

d. decrease PG in gaster

e. inhibit platelet

161. Chhronic, type Bateman?

a. Type A

b. Type B

c. Type C

d. Type D

e. Type E

162. A 25-years-old man takes 1 tablet of sedative hypnotic every night. On the 4^th day he needs 2 tablets. On the 7^th day he needs 4 tablets. Which of the following the response?

a. hyporeactive

b. hyposensitive

c. tachypylaxis

d. tolerance

e. addictive

163.

164. Which of the following causes hypersensitive?

Answer : histamin

165.

166.

167.

168. Which is the following is the MOA of Ampicillin?

a. inhibit the RNA

b. bound to nucleus

c. inhibit cell wall synthesis

d. inhibit protein synthesis

e. interfering enzyme reaction

169.

170. A woman takes jamu for pegal linu, after several weeks she always feel hungry. Which of the following drug is adulterated to the jamu?

a. prednisolon

b. ephedrine

c. paracetamol

d. ampicillin

e. antihistamin

171. Which of the following is the characteristic of phytopharmaca?

a. efficacy is unknown

b. without clinical trial

c. safety is known

d. modern packaging

e. consist of 2 active substance

172.

173. Yang menyebabkan terjadinya superinfeksi?

a. AB reduce

b. Toxin…

c. –

d. Penggunaan BSAB secara lama

e. –

174. Condition that cause accumulate AB

a. Brain dysfunction

b. Disturbed protein synthesis

c. Infarct myocard

d. TB pulmonary

e. Diabetes mellitus

175. Which of the following is the basic for choosing the appropriate AB?

a. the safety for patient

b. microbial finding

c. skin test of AM

d. the economical state of patient

e. depend on the most frequently used of AB in certain area

176.

177.

178.

179.

180. obat yang direkomendasikan untuk digunakan malam hari?

a. hyptonic-cemetidine-vaginal tablet-steroid preparation

b. anticholesterolemia-

c. anticholesterolemia-

d. anticholesterolemia-

e. anticholesterolemia-hypnotic-vaginal tablet-steroid preparation

181. From the following membrane, which is that orally administered of drug best absorb

a. colon

b. esophagus

c. gaster

d. small intestine

e. large intestine

182. How to increase bioavailability of drug..?

Answer : lowering intestinal motility

183.

184. The reason Vit.C is in solid dosage form?

a. solid form is stable

b. solid form is more rapid in absorption

c. solid form is cheaper than solution

d. solid form is convenience

185.

186. If 1= area under curve, 2=duration of action, 3=the highest drug plasma concentration, 4=the amount & rate of drug reacing systemic circulation, 5=the time needs of drug to achieving highest drug plasma concentration. Then which parameter determines the bioavailability of drugs?

a. 1,2,3,4

b. 2,3,4,5

c. 2,3,5,1

d. 4,2,3,5

187. The mechanism tetracycline penetrates the GI membrane is…

a. ion pairing

b. across pore

c. actice transport

d. passive diffusion

e. facilitate diffusion

188.

189. Paracetamol yang dosisnya paling banyak di pasaran..?

a. 100

b. 250

c. 300

d. 400

e. 500

for question no.190-193

f. Ointment

g. Gargles

h. Tinctures

i. Cream

j. –

190. semisolid preparation for external application to the skin/mucous membrane/emollient

191.

192. aqueous solution use for clearing the throat

193. made from vegetables

194.

195. Incline solubility..?

Answer : tablet-powder-solution

196.

197.

198.

199.

200.

Without number

Amoxicillin patio 120 ml

s.4.dd. 1.a.c.

Berapa ukuran 1 sendok teh..?

1. 5 ml
2. 8 ml
3. 10 ml
4. 15 ml
5. 20 ml

Jika dimakan 3 kali sehari, akan habis dalam berapa hari..?

1. 2 hari
2. 3 hari
3. 4 hari
4. 5 hari
5. 8 hari

Amoxicillin adalah water insoluble, maka bentuk sediaan obat harus dalam…

1. suspension
2. emulsion

Jika amoxicillin/ampicillin dimakan bersama antacid, maka pengaturannya adalah…

1. ampicillin 1.h.a.c. & antacid 1.h.p.c.
2. ampicillin 1.h.a.c. & antacid 1.h.a.c.
3. ampicillin 1.h.a.c. & antacid 2.h.p.c.
4. ampicillin 2.h.a.c. & antacid 2.h.a.c.
5. ampicillin 2.h.a.c. & antacid 2.h.p.c.

If adult single dose is 40 mg, the dose for 10 years old children is

1. 5 mg
2. 10 mg
3. 15 mg
4. 20 mg
5. 25 mg

Lab test determine autoimmune induce hepatitis

1. alpha-feto protein
2. anti nuclear antibody (ANA)
3. alpha-1-antiprypsin
4. LDH
5. Gamma-glutamiltransferase

Which of the following organism is important cause of chronic enterocolitis..?

1. Salmonella
2. Vibrio
3. Campylobacter
4. Yersenia enterocolitis
5. E.coli

Marker untuk clearance dari hepatitis B

1. HbsAg
2. AntiHbsA
3. AntiHCV
4. AntiHbe

Nb: temen2,,,sebenernya ini belum semua, tapi sisanya nyusul aja, ya...belum sempet nambah2in soalnya, nanti abis SOOCA deh dilengkapi..

semoga bisa bermanfaat ya...