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Kumpulan soal FBS III
1.A much more common technique for identification and location intercellular protein is to use spesific antibody probe. The antibodies recognize their particular antigen and bind tightly to antigenic molecules. This antigen antibody can be visualized by enzymatic secondary antibody probes. Which of the following is the most likely to be alive?
a.Immunofloresence
b.Immunocytochemistry
c.Polyclonal antibody production
d.SDS-PAGE
e.Western blotting
pembahasan: b. immunocytometry, lihat slide no.15 'HOW CELL ARE STUDIED'
2.The microscope which work with principle: absorbing light at spesific wavelenght and emits light at a spesific and longer wavelenght within a visible spectrum is ....
a.Light microscope
b.Immunofloresence microscope
c.Confocal scanning microscope
d.Phase contrast and normanski interference microscope
e.Transmission electron microscope
pembahasan: b.Immunofloresence microscope, lihat slide no.6 'HOW CELL ARE STUDIED'
3.Below is the reason why the biologists prefer to culture cell in laboratory, except...
a.experimental conditions can be controlled much more rigorously in culture than on an organism
b.a single cell can be readily grown into a colony
c.most animal and plant tissues are composed of several different types of cells
d.animal and plant tissues do not require rich media
e.all of the above
pembahasan: d.animal and plant tissues do not require rich media, lihat slide no. 24 'HOW CELL ARE STUDIED' , di situ dikatakan sebaliknya.
4.Which of these statements are not true?
Differentiation between eukaryotic an prokaryotic cells
| Eukaryotic | Prokaryotic |
| Have nuclear membrane | Have no nuclear membrane |
| Include animal and plant cells | Include all bacteria, eubacteria, archaebacteria |
| DNA is thread like material | DNA is in the form of a single circular molecule |
| Have no cell wall | Have cell wall |
| Have complex system and stucture | Have relatively simple structure |
pembahasan: d.eukaryot cell have no cell wall, pelajari slide 'ORGANIZATION OF CELL' tidak dikatakan bahwa sel eukaryot tak punya dinding sel, sel tumbuhan punya dinding sel.
5.Resolution ...
a.Not dependent at value of D
b.Is better when value of D is bigger
c.Decrease when the value of D decrease
d.Is better when wavelenght of incident light is shorter
e.Will be improved 4-fold when using such oils that have refractive index =2
pembahasan: d.Is better when wavelenght of incident light is shorter, lihat slide no.45 'ORGANIZATION OF CELL' point terakhir
6.The steps for preparing samples for light microscopy:
a.Fraction, sectioning, embedding, staining
b.Embedding, sectioning, staining, fraction
c.Fraction, embedding, sectioning, staining
d.Staining, fraction, embedding, staining
e.Fraction, staining, sectioning, embedding
pembahasan: c.Fraction, embedding, sectioning, staining, lihat slide no.49 'ORGANIZATION OF CELL'
7.The nucleopores has main function as :
a.Carrying genetic material
b.ynthesize protein
c.Regulates the movement of of the material from and to the nucleus
d.Maintain cell shape and mobility
e.Separate the cytoplasm and nucleoplasm
pembahasan: c.Regulates the movement of of the material from and to the nucleus, lihat slide no.10 'ORGANELLE STRUCTURE'
8.Maturation of secretory protein is begun in rough Endoplasmic Reticulum then carbohydrate chains of glycoprotein will be modified in ...
a.Vesicles
b.Smooth endoplasmic reticulum
c.Lysosome
d.Apparatus golgi
e.Ribosome
pembahasan: d.Apparatus golgi, lihat slide no.32 'ORGANELLE STRUCTURE'
9.Zellweger syndrome which has defective in oxidation of the very long chains fatty acids is caused by the transport of all proteins in this oraganelle is impaired. What is it and its function?
a.Ribosome, synthesis protein
b.Mithocondria, cell respiration
c.Apparatus Golgi, maturation of protein
d.Nucleus, storing genetic information
e.Peroxisome, contain peroxidase
pembahasan: e.Peroxisome, contain peroxidase lihat slide no.41 'ORGANELLE STRUCTURE'
10.Part of mithochondria
1).Inner membran
2).Outer membrane
3).Matrix
4).Cristae
Synthesis of ATP from ADP and Pi is occured in
a.1,2,3
b.1,3
c.2,4
d.4
e.1,2,3,4
pembahasan: b.1,3, lihat slide no.45 'ORGANELLE STRUCTURE'
11.Match the statement in the left with their properties in the right
1).Microfilament c a).Fibers with diameter 10 nm built with a common α-helical sub-unit
2).Microtubule b).Fibers with diameters 7-9 nm, grow by polimerization of actin
3).Intermediate filaments c).Fibers with diameters 24 nm grow by polimerization of tubulin
a.1-a, 2-b, 3-c
b.1-b, 2-c, 3-a
c.1-a, 2-c, 3-b
d.1-c, 2-b, 3-a
e.1-b, 2-a, 3-c
pembahasan: b.1-b, 2-c, 3-a, lihat slide no.2 'CYTOSKELETON'
12.What kind of cross-linking-protein that form a two dimensional meshwork that covers the cytoplasmic surface of the plasma membrane of red blood cells?
a.Spectrin
b.Myosin
c.Dystrophin
d.Filamin
e.Fascin
pembahasan: a.Spectrin, lihat slide no.22 'CYTOSKELETON'
13.Choose the best example of the function of dynamic microtubule
a.In epithelial cells, a bundle of actin and myosin filaments form a circumferential belt which encircle the inner surface of the cell at the level of the adherens junction.
b.Dystrophin anchors an integral membrane complex of glycoproteins to the cortical actin network
c.A neuronal cell is long-lived and seldom needs to establish new connections in a adult
d.About 10 keratins are specific for “hard” epithelial tissue, which give rise to nails, hair, and wool
e.During mitosis, the tubulin is used to form the spindle apparatus, which partitions chromosome equally to the daughter cells
pembahasan: e.During mitosis, the tubulin is used to form the spindle apparatus, which partitions chromosome equally to the daughter cells, lihat slide no.50 'CYTOSKELETON'
14.The protein that build intermediate filament which typically expressed in blood vessel, endothelial cells, in some ephitelial cells, and in mesenchymal cells such as fibroblast is...
a.Vimentin
b.Glial fibrillary acidic protein (GFAP)
c.Peripherin
d.Keratin
e.Actin
pembahasan: a.Vimentin, lihat slide no.66 'CYTOSKELETON'
15.Which is not true about amoeboid movement
a.Characterized by pseudopodial extension and cytoplasmic streaming
b.Accompanied by fluctuation of the cytoskeleton between “sol”and “gel” state
c.The energy used is gained from hydrolysis of ATP and release ADP and inorganic phosphate
d.Have a vigorous mechanism
e.The last step of movement the pseudopodium is still atached to the substratum
pembahasan: e.The last step of movement the pseudopodium is still atached to the substratum, lihat slide no.7 'CELL MOTILITY' point no3
a.contain two group: head goup contain glycerol- phosphate-choline, tail group contain two hydrocabon chains
b.play a major role in determine bilayer fluidity
c.the function is: tranportation, filter, cytoskeleton, receptor
d.stabilize protein
16.Match each number to their properties
a.1-a, 2-b, 3-c, 4-d
b.1-b, 2-c, 3-d, 4-a
c.1-b, 2-c, 3-a, 4-d
d.1-b, 2-a, 3-b, 4-c
e.1-b, 2-a, 3-d, 4-d
pembahasan: c.1-b, 2-c, 3-a, 4-d, pelajari slide no. 7-42 'CELL MEMBRANE'
17.Which is false?
a.Osmosis is the net movement of a solvent in through a selectively permeable membrane
b.The rate of facilitated diffusion is determined by the steepness of the concentration gradient across the membrane
c.Active transport requires energy ionic concentration gradient
d.In osmosis,water flows from lower to higher water concentration
e.Na+ ions always move down-hill and the others always up-hill
pembahasan: d.In osmosis,water flows from lower to higher water concentration,lihat slide no. 13 'PHYSIOLOGICAL FUNCTION OF PLASMA MEMBRANE
18.The sequence of endocytosis
1)Binding of LDL molecules to its specific receptor
2)Recycling the receptor
3)Invaginated membrane form clathrin-coated vesicle containing receptor-LDL complex
4)The clathrin-coated pit loses and back to the membrane
5)The uncoated vesicle fuses with endosom
6)Degradation in lysosom
Arrange to make the true sequence:
a.1-2-4-5-3-6
b.1-3-5-4-2-6
c.1-3-4-5-6-2
d.1-3-4-5-2-6
e.1-3-2-5-4-6
pembahasan: d.1-3-4-5-2-6, lihat slide no. 26 'PHYSIOLOGICAL FUNCTION OF PLASMA MEMBRANE'
19.What doesn't happen in metaphase?
a.The forming of spindle of apparatus microtubules make contact with and attached to the kinetochore of the condensed chromosome
b.Chromosomes begin to undergo a series of movement of all of the chromosome at the equator of the spindle
c.Chromosomes are haphazardly scaterred arround the mitotic spindle
d.the chromatids begin their migration or segregation toward opposite poles of spindle
e.All of the above
pembahasan: d.the chromatids begin their migration or segregation toward opposite poles of spindle, lihat slide no.19 (kalo nggak salah) 'CELL DIVISION & CELL CYCLE', opsi d itu terjadi di anaphase
20.Gap junction...
a.Is 2 identical plasma membrane channels join
b.Lends strenght to the cells
c.Allows cell to communicate
d.Allows small molecules and ions to pass
e.All of the above
pembahasan: e.All of the above, lihat slide no.16 (kalo nggak salah) 'CELL DIVISION & CELL CYCLE'
Kumpulan soal fbs 4
1.Chromosome from somatic cell of a normal woman consists of ...
a.44 autosomes and 1 chromosome X
b.22 pairs of autosomes and 1 chromosome X
c.23 pairs of autosomes and a pair of chromosome X
d.44 autosomes and a pair of chromosome X
e.22 autosomes and a pair of chromosome X
pembahasan: d.44 autosomes and a pair of chromosome X, lihat slide no.7 'HUMAN GENETIC'
2.Down syndrome ...
a.Caused by crossing over
b.Sterile or infertile
c.Has fold of skin on the back of the neck
d.Has very long arms and legs
e.the present of an additional number 21 chromosomes
pembahasan: e.the present of an additional number 21 chromosomes, lihat slide no.68 'HUMAN GENETIC'
3.Read the case carefully:
The marriage between a woman and a man who has a normal vision generate a son who is color blind and two daughters that has normal vision.
From case above we can infer that :
a.The mother is dominant homozygote
b.The mother is recessive homozygote
c.The mother is carrier
d.The father is carrier
e.The father is dominant homozygote
pembahasan: gen buta warna merupakan sifat terpaut sex resesif (Xcb) buta warna pada anak laki2 diwarisi dari ibunya, pada anak perempuan diwarisi dari ayah dan ibunya,
c. the mother is carrier
4.Which is true statement about pharmacogenenetics
a.Pharmacogenetics is the study of drugs in response to genetic disorder
b.Glucose-6-phosphate dehydrogenase deficiency(G6PD) is condition where interfere significantly glucose metabolism
c.Succinylcholine is nearly always inactivated rapidly by the serum enzym, that breaks down acetylcholine, thus limiting its active life in the body to four minutes or less
d.Hepatic porphyria refer to a group of metabolic disorders manifested in some types photosensitive skin lessions
e.People with the mutant allele for resistance require a much lower dose of warfarin than normal people to produce the blood coagulation
pembahasan: d.Hepatic porphyria refer to a group of metabolic disorders manifested in some types photosensitive skin lessions, lihat slide no.100 'HUMAN GENETIC'
Look at the picture below
5.What is the part of ovum that is passed trough by sperm in phase 2 in fertilization?
a.Ovum cell wall
b.Corona radiata
c.Corona pellucida
d.Zona pellucida
e.Oocyte membrane
pembahasan: d.Zona pellucida, lihat slide no.39 'EMBRYOLOGY'
6.Fill the schematic diagram below about zygote development
a.Morulla, blastocyst, trophoblast, embryoblast, hypoblast, epiblast, cytotrophoblast, syncythiotropoblast
b.Morulla, blastocyst, embryoblast, trophoblast, hypoblast, epiblast, cytotrophoblast, syncythiotropoblast
c.Morulla, blastocyst, embryoblast, trophoblast, cytotrophoblast, syncythiotropoblast, hypoblast, epiblast
d.Morulla, blastocyst, trophoblast, embryoblast, cytotrophoblast, syncythiotropoblast, hypoblast, epiblast
e.Morulla, blastocyst, trophoblast, embryoblast, hypoblast, epiblast, cytotrophoblast, syncythiotropoblast
pembahasan: b.Morulla, blastocyst, embryoblast, trophoblast, hypoblast, epiblast, cytotrophoblast, syncythiotropoblast, lihat slide no.41-47 'EMBRYOLOGY'
7.Sequence of heart development in organogenesis:
1)Splancnic mesoderm
2)Single heart
3)Cardiogenic plate
4)Covered by endocardium, myocardium, epycardium
5)Cardiac primordia
The best arrangement is
a.1-2-3-4-5
b.1-3-5-2-4
c.1-3-2-5-4
d.1-3-4-2-5
e.1-3-5-4-2
pembahasan: b.1-3-5-2-4, lihat slide no.105 'EMBRYOLOGY'
8.Which is incorrect statement about dyzygotic twins?
a.They may have the same sex
b.Result from simultaneous shedding of two oocytes and fertilization by two spermatozoa
c.The zigote implant individually in the uterus, and develop its own placenta, amnion and chorionic sac
d.is identical twins
e.Is the most frequent twins happen
pembahasan: d.is identical twins, lihat slide no.4-7 'TWINS & TERATOLOGY'
9.“Fetal alcohol syndrome”...
a.Craniofacial abnormalities (short palpebral fissures and hypoplasia of the maxilla )
b.Limb deformities (altered joint mobility and position)
c.Cardiovascular defects (ventricular and septal abnormalities)
d.Mental retardation and growth deficiency
e.All of the above
pembahasan: e.All of the above, lihat slide no.39 'TWINS & TERATOLOGY'
10.Which is wrong statement about differentiation between structure of DNA and RNA
DNA RNA
a.Double strands molecule Single strands molecule
b.Bigger size than RNA Smaller size than DNA
c.Contains deoxyribose as pentose sugar Contains ribose pentose sugar
d.Only found in nucleus Only found in cytoplasm
e.Contains thymine as nitrogen base Contains uracyl as nitrogen base
pembahasan: d.DNA only found in nucleus, kan ada DNA mitokondria,
11.What is the function of enzyme helicase
a.Deoxynucleotide polimerization
b.Processive unwinding of DNA
c.Initiates synthesis of RNA primers
d.Prevent premature reannealing of double strand DNA
e.Seals the single strand nick between the nascent chain and Okazaki fragment on lagging strand
pembahasan: b.Processive unwinding of DNA, lihat slide ujung kiri atas hal 368 buku slide yang dikeluarkan oleh Dept. Akademik. di Harper juga ada tabel no36-5.
12. original codon UCU Þ serine
new codon UCA Þ serine
what kind of mutation above?
a.frame-shift mutation
b.mis-sense mutation
c.abberation mutation
d.silent mutation
e.translocation mutation
pembahasan: d.silent mutation, lihat slide hal 244 buku slide yang dikeluarkan oleh Dept. Akademik.
13.tRNA...
a.Serves as template on which specific sequence of amino acids is polymerized to form a specific protein molecule
b.Is a double stranded molecule
c.Acts as machinery for the synthesis of proteins from the mRNA templates
d.Serves as adapters for the translation of mRNA into specific amino acids
e.play key roles in the binding of mRNA to ribosomes and its translation
pembahasan: d.Serves as adapters for the translation of mRNA into specific amino acids, aku dapetnya dari slide no. 6 RNA nama filenya 'DR TRI'. di harper juga ada.
14.In which phase of protein synthesis, peptide bond formation is occured?
a.Initiation
b.Elongation
c.Termination
d.All of the above
e.None of above
pembahasan: b.Elongation, dah jelas kan? lihat slide no. 12 nama file 'Genetic codes and codons01'
15.These statements are explain about trancription in prokaryotes, which is false?
a. transcription and translation is located within same cellular compartment
b.promoter is TATAAT (Pribnow box) at base -10 from startpoint
c.primary transcripts directly use for translation
d.there are three classes of RNA polymerase : I, II, III
e.promoter is TTGACA sequence close to startpoint (-35)
pembahasan: d.there are three classes of RNA polymerase : I, II, III, lihat slide hal 348 buku slide yang dikeluarkan oleh Dept. Akademik.
16. Which is not the features of the genetic code
a.generate
b.non-overlapping
c.universal
d.unambigious
e.non-punctuated
pembahasan: a.generate, lihat slide no. 6 nama file 'Genetic codes and codons01'. harusnya degenerate
17.Polymerase chain reaction(PCR)...
a.step annealing need high temperature (90o-94oC)
b.enzyme used is isolated from E.coli
c.started with annealing step
d.buffer used is consist of tris, KBr, MgI2
e.the last step is extension a complementary DNA strand
pembahasan: e.the last step is extension a complementary DNA strand, lihat lab manual bagian laboratory activity
18.1)GENE Þ 2)PRIMARY TRANSCRIPT Þ 3)mRNA Þ 4)PROTEIN
Process no 3 to be no 4 is called
a.replication
b.transcription
c. modification
d.translation
e.degradation
pembahasan: d.translation, lihat slide Dr. Tri no.5
19.Sequence of replication in eukaryotic cell
1)antigen T binds to the origin of replication
2)primase creates a primer for the beginning of replication
3)antigen T separartes strands DNA into 2 DNA strands
4)forming replication fork
the correct sequence is
a.1-2-4-3
b.1-3-2-4
c.1-3-4-2
d.1-2-4-3
e.1-2-3-4
pembahasan: c.1-3-4-2, lihat slide 'Replication D5' no.12
20.Which is not a kind of regulation at level DNA
a.gene loss
b.activation of spesific gene
c.chemical modification of DNA
d.gene amplification
e.gene rearrangement
pembahasan: c.chemical modification of DNA. karena termasuk regulasi tingkat transkripsi
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